Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial

P. S. Sándor, MD, L. Di Clemente, MD, G. Coppola, MD, U. Saenger, A. Fumal, MD, D. Magis, MD, L. Seidel, MSc, R. M. Agosti, MD and J. Schoenen, MD, PhD
NEUROLOGY 2005;64:713-715

ABSTRACT

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

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