Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society
Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012 Apr 24;78(17):1346-53. [24 references]
Major Recommendations
Definitions of the levels of the recommendations (A, B, C, U) and classification of the evidence (Class I-IV) are provided at the end of the “Major Recommendations” field.
Conclusions
- Petasites is established as effective for migraine prevention (2 Class I studies).
- Riboflavin is probably effective for migraine prevention (1 Class I trial and 1 imprecise Class II study).
- Co-Q10 is possibly effective for migraine prevention (1 Class II study).
- A combination of soy isoflavones (60 mg), dong quai (100 mg), and black cohosh (50 mg) is possibly effective for migraineprevention (1 Class II study). Percutaneous estradiol is possibly effective for migraine prevention (1 Class II study); however, there is an increased risk of migraine recurring after estradiol patch discontinuation.
- Magnesium is probably effective for migraine prevention (multiple Class II trials). MIG-99 (feverfew) is probably effective for migraine prevention (1 Class I study, 1 positive Class II study, and 1 underpowered negative Class II study).
- The efficacy of hyperbaric oxygen (HBO) for migraine prevention is unclear (1 imprecise negative Class II study).
- The efficacy of omega-3 for migraine prevention is unclear (1 imprecise Class I study).