Reference: “Ubiquinol (Q10H2) reduces gamma glutamyltransferase (GGT) as a marker of oxidative stress in humans,” Onur S, Niklowitz P, et al, BMC Res Notes 2014 Jul 4; 7(1): 427. (Address: Institute of Human Nutrition and Food Science, Division of Molecular Prevention, Christian Albrechts University Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany. E-mail: sek@molprev.uni-kiel.de ).
Summary: In this study involving 469 subjects, it was found that ubiquinol, a reduced form of coenzyme Q10 (CoQ10), had a significant positive effect on oxidative stress in humans. In the first part of the study, the relationship between CoQ10 status and GGT activity (associated with CVD) was examined in 416 healthy subjects aged 19 to 62 years. In the second stage, 53 healthy males aged 21 to 48 years were given ubiquinol supplementation (150 mg/d, for 14 days). There was a strong positive association between CoQ10 and serum GGT activity, which included differences between male and female subjects. Oxidative stress events declined sharply in lipids, proteins, and DNA. GGT1 gene expression mRNA levels declined 1.49-fold after ubiquinol supplementation. The authors conclude that “higher Q10H2 levels improve oxidative stress via reduction of serum GGT activity in humans.”