High-density lipoproteins and coronary artery disease: a single-center cohort study
Angiology, 08/25/2014 Evidence Based Medicine Clinical Article
Schaffer A, et al. – The goal was to estimate the role of high–density lipoprotein cholesterol (HDL–C) in predicting the prevalence and extent of coronary artery disease (CAD) in 3280 patients undergoing coronary angiography.
Methods
- Predictors of lower HDL levels (<32 mg/dL) were male gender (P < .001), diabetes mellitus (P = .03), renal failure (P = .01), higher low–density lipoprotein and total cholesterol (P < .001, respectively), triglycerides (P < .001), and white blood cells (P < .001), aging (P < .001), previous myocardial infarction (P = .02) and hemoglobin (P < .001), treatment with angiotensin–receptor blockers (P < .001), and statins (P = .002).
Results
- The HDL–C levels were significantly inversely associated with prevalence of CAD (P < .001, adjusted odds ratio [OR] [95% confidence interval, CI] = 1.35 [1.25–1.45], P < .001), and HDL–C <44 mg/dL was best the predictive value of the risk of CAD, (adjusted OR [95%CI] = 1.61 [1.24–2.1], P < .001).
- Authors found significant association between HDL–C and the risk of CAD; a value <44 mg/dL was the best cutoff in the prediction of CAD.
Angiology. 2014 Sep;65(8):696-702. doi: 10.1177/0003319713502253. Epub 2013 Sep 18.
High-density lipoproteins and coronary artery disease: a single-center cohort study.
Schaffer A1, Verdoia M1, Barbieri L1, Aprami TM2, Suryapranata H3, Marino P1, Luca GD4; Novara Atherosclerosis Study Group (NAS).
Abstract
Our goal was to estimate the role of high-density lipoprotein cholesterol (HDL-C) in predicting the prevalence and extent of coronary artery disease (CAD) in 3280 patients undergoing coronary angiography. Predictors of lower HDL levels (