Cardiology — Abdelfattah R, et al. | July 06, 2018
A meta-analysis, including a dose-response analysis, was performed to evaluate the correlation between caffeine consumption and occurrence of atrial fibrillation (AF). They analyzed data from selected studies representing 176,675 subjects (AF in 9,987 [5.7%]). Findings revealed no increase in the AF occurrence by coffee consumption. Conversely, when caffeine consumption exceeded 436 mg/day, a lower incidence of AF was noted. Therefore, the available evidence suggests no association between caffeine intake and AF risk.
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Abstract
Objective: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF. Methods: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee. Results: No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937–1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily. Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.
© 2018 S. Karger AG, Basel