Digestive and Liver Diseases — Ivancovsky-Wajcman D, et al. | July 10, 2019

In this cross-sectional study involving a large cohort of subjects undergoing colonoscopy, researchers explored the association of dietary vitamins E and C intakes with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis markers. NAFLD’s presence was assessed by ultrasonography. Overall, the study sample consisted of 789 participants, and 714 had reliable FibroMax. Upon adjusting for body mass index, and dietary and lifestyle factors, the upper tertile of vitamin E intake/1,000 Kcal was linked to lower odds of NASH. An inverse association was noted between reaching the recommended vitamin E intake and NASH. The upper tertile of vitamin C intake/1,000 Kcal was related to lower odds of NAFLD and NASH. According to SteatoTest, both vitamins were associated with the level of steatosis. Overall, the authors concluded that vitamin E and C intakes can be protective against liver damage associated with NAFLD.

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