American Journal of Epidemiology, 07/28/2015
Epstein M, et al.
The authors performed the first investigation of an association between dietary pattern and cHL risk in 435 cHL cases and 563 population–based controls from Massachusetts and Connecticut (1997–2000) who completed baseline diet questionnaires. Other dietary patterns were not clearly associated with cHL. They report the first evidence for a role of dietary pattern in cHL etiology. Diets featuring high intake of meat or desserts and sweets may increase cHL risk.
- They identified 4 major dietary patterns (“vegetable,” “high meat,” “fruit/low–fat dairy,” “desserts/sweets”) using principal components analysis.
- They computed multivariable odds ratios and 95% confidence intervals for associations of dietary pattern score (quartiles) with younger–adult (age <50 years), older–adult (age ≥ 50 years), and overall cHL risk.
- Secondary analyses examined associations by histological subtype and tumor Epstein–Barr virus (EBV) status.
- A diet high in desserts/sweets was associated with younger–adult (odds ratio(quartile 4 vs. quartile 1) = 1.60, 95% confidence interval: 1.05, 2.45; Ptrend = 0.008) and EBV–negative, younger–adult (odds ratio = 2.11, 95% confidence interval: 1.31, 3.41; Ptrend = 0.007) cHL risk.
- A high meat diet was associated with older–adult (odds ratio = 3.34, 95% confidence interval: 1.02, 10.91; Ptrend = 0.04) and EBV–negative, older–adult (odds ratio = 4.64, 95% confidence interval: 1.03, 20.86; Ptrend = 0.04) cHL risk.