Research · April 27, 2014 TAKE-HOME MESSAGE In this large meta-analysis of 82 studies evaluating the association between obesity and breast cancer survival, investigators found that increased BMI before or after breast cancer diagnosis and treatment was associated with a significant increased risk of total and breast cancer–specific mortality, in both pre- and post-menopausal women. This […]
Journal of the National Cancer Institute, 04/21/2014 Clinical Article Sieri S, et al. – High saturated fat was statistically significantly associated with greater risk of HER2- disease. High saturated fat intake particularly increases risk of receptor–positive disease, suggesting saturated fat involvement in the etiology of this BC subtype. Abstract We prospectively evaluated fat intake […]
Results from the selenium and vitamin E cancer prevention trial Cancer Epidemiology, Biomarkers & Prevention, 04/18/2014 Clinical Article Kristal AR, et al. – The results of this study suggests that both low and high vitamin D concentrations were associated with increased risk of prostate cancer, and more strongly for high–grade disease. Methods Data for this case (n=1,731)–cohort […]
Nikola Biller-Andorno, M.D., Ph.D., and Peter Jüni, M.D. April 16, 2014DOI: 10.1056/NEJMp1401875 Journal Reference In January 2013, the Swiss Medical Board, an independent health technology assessment initiative under the auspices of the Conference of Health Ministers of the Swiss Cantons, the Swiss Medical Association, and the Swiss Academy of Medical Sciences, was mandated to prepare […]
Conference Coverage Practice Update Tony Nimeh MD Friday May 16 1 – 5 p.m. Orange County Convention Center: Chapin Theater Moderator: Fritz H. Schroder, M.D. Pro: H. Ballentine Carter, MD Pro: Ian M. Thompson, Jr, MD Con: William J. Catalona, MD Con: Issac Powell Summary of the PRO arguments: 1- The guidelines follow the AUA […]
European Urology, 04/14/2014 Clinical Article Full Story PubMed Reference Journal Reference Kenfield SA, et al. – This study aims to determine whether the traditional Med–Diet pattern is associated with risk of incident advanced or lethal PCa and with PCa–specific and overall mortality among men with PCa. A higher Med–Diet score was not associated with risk of advanced […]
Systematic review and meta-analysis of observational cohort and randomised intervention studies Chowdhury R, et al. Show all BMJ. 2014 Apr 1;348:g1903. doi: 10.1136/bmj.g1903. Comment in BMJ. 2014;348:g2280. Abstract OBJECTIVE: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. DESIGN: Systematic review and […]
Medscape Medical News Larry Hand April 10, 2014 Use of sildenafil (Viagra, Pfizer) is associated with an increased risk for melanoma, according to an article published online April 7 in JAMA Internal Medicine. Researchers caution, however, that their study does not provide sufficient evidence to change clinical recommendations for erectile dysfunction (ED) treatments. Wen-Qing Li, PhD, from the […]
A systematic review and meta-analysis Annals of Oncology, 03/25/2014 Review Article Schmid D, et al. – Using prospective studies published through June 2013, the authors conducted a systematic review and random–effects meta–analysis of pre– and post–diagnosis physical activity in relation to total and cancer mortality among breast or colorectal cancer survivors. Physical activity performed before or after […]
A systematic review and meta-analysis Annals of Oncology, 03/25/2014 Review Article Schmid D, et al. – Using prospective studies published through June 2013, the authors conducted a systematic review and random–effects meta–analysis of pre– and post–diagnosis physical activity in relation to total and cancer mortality among breast or colorectal cancer survivors. Physical activity performed before […]
Fran Lowry March 24, 2014 Obese women could reduce their risk of developing uterine cancer by as much as 70% with bariatric surgery, according to new research. And if the women maintain a normal weight after surgery, this dramatic decrease in risk is even better — up to 81%, said lead investigator Kristy Ward, MD, […]
New England Journal of Medicine, 03/21/2014 Evidence Based Medicine Clinical Article Imperiale TF, et al. – An accurate, noninvasive test could improve the effectiveness of colorectal–cancer screening. In asymptomatic persons at average risk for colorectal cancer, multitarget stool DNA testing detected significantly more cancers than did FIT but had more false positive results. Methods Authors compared a […]
by Charles Bankhead Staff Writer, MedPage Today March 19, 2014 A stool DNA test detected significantly more colon cancers in average-risk patients as compared with a conventional fecal immunochemical test (FIT), a large prospective clinical study showed. The DNA test detected 92.3% of colorectal cancers versus 73.8% for FIT in a study involving almost 10,000 […]
Wednesday, 19 Mar 2014 08:26 AM A novel colon cancer test from Exact Sciences Corp. (EXAS) and the Mayo Clinic using the DNA of specimens that patients collect at home detects more tumors than methods focusing on blood in the stool, a study found. The research released Tuesday by the New England Journal of Medicine […]
Research · March 17, 2014 Full Story Journal Reference TAKE-HOME MESSAGE In a randomized clinical trial of 4203 patients between the ages of 50 and 85 years with intermediate/advanced age-related macular degeneration in one eye, daily supplementation with ω-3 fatty acids and lutein + zeaxanthin did not reduce the risk of cardiovascular disease (CVD) or secondary CVD […]
Fran Lowry March 13, 2014 Women with high levels of vitamin D in their blood when they are diagnosed with breast cancer are almost twice as likely to survive as those with low levels of vitamin D, according to a meta-analysis published in the March issue of Anticancer Research. The meta-analysis looked at 5 studies of serum 25-hydroxyvitamin D (25[OH]D) […]
Research · March 12, 2014 Full Story Journal Reference TAKE-HOME MESSAGE A meta-analysis of 31 studies found that indoor tanning increases the odds of melanoma by 16% overall (23% in North America). There is a further increased risk of developing melanoma with more than 10 tanning sessions and with using indoor tanning prior to age […]
European Journal of Cancer, 03/04/2014 Evidence Based Medicine Review Article Clinical Article PubMed Reference Maalmi H, et al. – This studya ims to estimate the association between serum 25–hydroxyvitamin D (25(OH)D) levels and survival among colorectal and breast cancer patients. Higher 25(OH)D levels (>75nmol/L) were associated with significantly reduced mortality in patients with colorectal and breast cancer. […]
Nick Mulcahy February 26, 2014 New data from the much publicized Selenium and Vitamin E Cancer Prevention Trial (SELECT), which sought to determine whether these supplements could protect against the development of prostate cancer, confirm that both antioxidants can be risky business for men. As previously reported, men receive no preventive benefit from either selenium […]
A meta-analysis of randomized controlled trials BMC Public Health Zhang YF, et al. – Omega–3 fatty acids are known to prevent cardiac death. However, previous observational studies have suggested that omega–3 fatty acids are associated with cancer risk in adults. The authors conducted a meta–analysis based on randomized controlled trials to evaluate the effect of […]