Interleukin-17 (IL-17)

What may be lurking at the root of psoriasis?

Michael Jurgelewicz, DC, DACBN, DCBCN Psoriasis is an inflammatory skin condition that is characterized by itchy, scaly skin plaques. The exact cause of psoriasis is unknown; however, more and more evidence suggests that the immune system can be a culprit when it is chronically stimulated, causing an overproduction of cytokines, which maintains an inflammatory environment. […]

What’s the Link? Psoriasis and Heart Failure

PracticeUpdate.com Peter Libby MD In a recent article published in the European Journal of Heart Failure, Dr. Usman Khalid and colleagues interrogated the national database of Denmark to probe the link between psoriasis and the risk for heart failure.1 They followed a cohort for 14 years and identified psoriasis diagnoses by identifying individuals who received prescriptions for topical vitamin […]

Role of cytokines in intervertebral disc degeneration: pain and disc content

Nat Rev Rheumatol. 2014 Jan;10(1):44-56. doi: 10.1038/nrrheum.2013.160. Epub 2013 Oct 29. Risbud MV, Shapiro IM. Abstract Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and radicular pain. IVD degeneration is characterized by increases in levels of the proinflammatory cytokines TNF, IL-1α, IL-1β, IL-6 and IL-17 secreted by the IVD cells; […]