Interleukin-6 (IL-6)

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

The Spine Journal VOLUME 22, ISSUE 2, P214-225, FEBRUARY 01, 2022 Highlights •  Early transiently raised C-reactive protein associated with good long-term recovery after acute back pain. •  Persistent tumor necrosis factor overexpression associated with poor long-term recovery after acute back pain. •  Psychological and sleep status during acute back pain did not predict future […]

Effects of spinal manipulative therapy on inflammatory mediators in patients with non-specific low back pain: a non-randomized controlled clinical trial

Chiropr Man Therap. 2021 Jan 8;29(1):3. doi: 10.1186/s12998-020-00357-y. Julita A Teodorczyk-Injeyan Abstract Background: The inflammatory profiles of patients with acute and chronic nonspecific low back pain (LBP) patients are distinct. Spinal manipulative therapy (SMT) has been shown to modulate the production of nociceptive chemokines differently in these patient cohorts. The present study further investigates the […]

Pulsed Electromagnetic Fields Reduce Interleukin-6 Expression in Intervertebral Disc Cells Via Nuclear Factor-κβ and Mitogen-Activated Protein Kinase p38 Pathways

Spine: November 15, 2019 – Volume 44 – Issue 22 – p E1290-E1297 doi: 10.1097/BRS.0000000000003136 Tang, Xinyan PhD Study Design. This is an in vitro study of bovine disc cells exposed to pulsed electromagnetic fields. Objective. The purpose of the present study was to investigate whether pulsed electromagnetic fields (PEMF) effects on the expression of […]

Non-specific Low Back Pain: Inflammatory Profiles of Patients with Acute and Chronic Pain.

Clin J Pain. 2019 Jul 5. doi: 10.1097/AJP.0000000000000745. [Epub ahead of print] Teodorczyk-Injeyan JA1, Triano JJ1, Injeyan HS2. Abstract BACKGROUND: The pathogenesis of low back pain (LBP) remains unclear. However, recent studies suggest that the inflammatory response may be inherent in spinal pain. PURPOSE: To discern inflammatory profiles in patients with non-specific acute and chronic […]

The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

Phytother Res. 2019 Feb;33(2):253-262. doi: 10.1002/ptr.6226. Epub 2018 Nov 7. Tabrizi R1, Vakili S2, Akbari M1, Mirhosseini N3, Lankarani KB1, Rahimi M4, Mobini M5, Jafarnejad S6, Vahedpoor Z7, Asemi Z6. Abstract Besides other benefits, curcumin is getting more recognized for its antioxidant and anti-inflammatory properties, highlighting the importance of curcumin application for chronic disease prevention. […]

Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis – Full Text Article

Mediators Inflamm. 2018; 2018: 1094352. Published online 2018 Apr 2. doi: 10.1155/2018/1094352 PMCID: PMC5901481 PMID: 29805310 Tábata Cristina do Carmo Almeida,corresponding author 1 Francisco Winter dos Santos Figueiredo, 1 Valter Cordeiro Barbosa Filho, 2 Luiz Carlos de Abreu, 3 Fernando Luiz Affonso Fonseca, 4 and Fernando Adami 1 Abstract The mechanism of pain reduction involves […]

Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects

Clin Nutr. 2018 Mar 13. pii: S0261-5614(18)30118-3. doi: 10.1016/j.clnu.2018.03.006. [Epub ahead of print] López-Chillón MT Abstract BACKGROUND & AIMS: Broccoli sprouts represent an interesting choice of healthy food product as they are rich in glucosinolates and their cognate bioactive metabolites, isothiocyanates able to counteract the negative effects of diverse pathologies. As obesity is linked to […]

Mindfulness meditation lowers stress hormone and decreases inflammation in body, scientists find

Sarah Knapton 24 JANUARY 2017 Mindfulness meditation, the practice of paying more attention to the present moment, helps lower stress hormones and decreases inflammation in the body, scientists have proven for the first time. The training has been growing in popularity in recent years, with the NHS recommending mindfulness as a way to reduce stress and […]

Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study

Spine: February 2016 – Volume 41 – Issue 3 – p 197–203 doi: 10.1097/BRS.0000000000001214 de Queiroz, Bárbara Zille PhD Abstract Study Design. Cross-sectional study with subsample of elderly women with acute low back pain (LBP), from Back Complaints in the Elders-Brazil (BACE-Brazil) Objective. To investigate the association between plasma levels of mediators of inflammation (interleukin-1 […]

New approach to diagnosing low back pain, revealed by clinical study

Date: January 7, 2016 Source: North Shore-Long Island Jewish (LIJ) Health System Summary: A new, personalized approach to diagnosing low back pain has been discovered by researchers. Low back pain is the second most common cause of physician visits in the US and contributes to an estimated $100 billion in US costs per year, making […]

Fish oil supplementation does not lower C-reactive protein or interleukin-6 levels in healthy adults

Journal of Internal Medicine, 11/03/2015 Muldoon MF, et al. The n–3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may prevent a range of chronic conditions through anti–inflammatory actions. However, as clinical trials using these fatty acids for primary prevention are yet unavailable, their putative role in disease prevention rests, in part, on […]

Inflammation, not telomere length, predicts healthy longevity of centenarians

August 5, 2015 Scientists have cracked the secret of why some people live a healthy and physically independent life over the age of 100. For the first time, a team of experts from Newcastle University’s Institute for Ageing and Keio University School of Medicine, Tokyo, explored which biological and pathological processes may be the most […]

Inflammation in intervertebral disc degeneration and regeneration – Full Text Article

Journal of the Royal Society Interface Maria Molinos, Catarina R. Almeida, Joana Caldeira, Carla Cunha, Raquel M. Gonçalves and Mário A. Barbosa Published:06 March 2015 https://doi.org/10.1098/rsif.2014.1191 Abstract Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as […]

Therapeutic potential of Panax ginseng and ginsenosides in the treatment of chronic obstructive pulmonary disease

Complementary Therpies in Medicine Published Online: August 20, 2014 DOI:http://dx.doi.org/10.1016/j.ctim.2014.08.006 Highlights The authors reviewed Panax ginsengand ginsenosides for their potential to treat COPD. Experimental cell and animal studies were evaluated. Panax ginseng and ginsenosides have anti-inflammatory and anti-oxidative effects. Panax ginseng and ginsenosides may be suitable therapeutic targets for the treatment of COPD. Summary Background Chronic obstructive pulmonary […]

Does Inflammation Increase Fracture Risk?

By Salynn Boyles Reviewed by Vrunda Bhavsar Desai, MD, FACOG, Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT Article Source Take Note Inflammatory burden may be an important biological risk factor for osteoporosis and hip fracture in older women. At least 10 observational studies have examined the […]

Does stress affect the joints? Daily stressors, stress vulnerability, immune and HPA axis activity, and short-term disease and symptom fluctuations in rheumatoid arthritis

Ann Rheum Dis. 2014 Sep;73(9):1683-8. doi: 10.1136/annrheumdis-2012-203143. Epub 2013 Jul 9. Evers AW Abstract OBJECTIVES: Both stressors and stress vulnerability factors together with immune and hypothalamus-pituitary-adrenal (HPA) axis activity components have been considered to contribute to disease fluctuations of chronic inflammatory diseases, such as rheumatoid arthritis (RA). The aim of the present study was to […]

Autoimmunity: Pollution, and Particles Asbestos, Air Pollution and Nanoparticles

Published: Aug 13, 2014 By Nancy Walsh, Senior Staff Writer, MedPage Today Action Points There is some evidence that particulate air pollution may influence risk for and expression of autoimmune disease. A particular role for nanoparticles in human disease has not been established. Recently, I wrote an article about some interesting research being done by Jean Pfau, […]

Exercise Cuts Cytokines in Prostate Cancer

Published: Jun 2, 2014 By Ed Susman , Contributing Writer, MedPage Today CHICAGO — A structured physical exercise program appears to reduce cytokine production related to depression and inflammatory processes that may impact prostate cancer progression, researchers said here. Patients receiving usual care experienced a 0.08 log10 increase in pro-inflammatory interleukin-6 production, while patients treated […]

Association between baseline IL-6 and 1-year recovery in lumbar radicular pain

Eur J Pain. 2014 Nov;18(10):1394-401. doi: 10.1002/j.1532-2149.2014.502.x. Epub 2014 Apr 2. Schistad EI, Espeland A, Pedersen LM, Sandvik L, Gjerstad J, Røe C. Abstract BACKGROUND: In the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined. METHODS: In total, 110 patients with symptomatic lumbar disc herniation were followed for […]

Lack of Vitamin D Linked to CVD Biomarkers, Inflammation

Marlene Busko February 27, 2014 COLERAINE, UK — Older, healthy individuals who were deficient in 25-hydroxy vitamin D (vitamin D) tended to have higher levels of biomarkers linked with CVD and inflammatory conditions such as multiple sclerosis and rheumatoid arthritis, in an observational study[1]. More specifically, individuals who had a vitamin-D deficiency had significantly higher […]