Genetics

Behavior, Biology Make it Hard to Keep Pounds Off

Published: Dec 15, 2014 By Kristina Fiore, Staff Writer, MedPage Today Maintaining weight loss is foiled by a combination of behavioral challenges and physiological adaptations that promote weight gain, according to a new report from a National Institutes of Health working group. Behavioral fatigue is a big problem, causing patients to grow weary of diet […]

How standing might be the best anti-ageing technique

By Sarah Knapton, Science Correspondent 12:00AM BST 04 Sep 2014 Spending less time on the sofa lengthens ‘telomeres’ – the caps on chromosomes which protect the genetic code inside The best anti-ageing technique could be standing up, scientists believe, after discovering that spending more time on two feet protects DNA. A study found that too much […]

Study Suggests Potential Parent–Child Link in Chronic Musculoskeletal Pain

POSTED: AUGUST 18, 2014 Children with parents who have chronic musculoskeletal pain (CMP) are at a higher risk for developing CMP, a new family-linkage study finds. According to researchers from the Norwegian University of Science and Technology in Trondheim, CMP is “among the leading causes of reduced quality of life and disability in Western countries,” […]

Screening an Asymptomatic Person for Genetic Risk

N Engl J Med 2014; 370:2442-2445 June 19, 2014DOI: 10.1056/NEJMclde1311959 CASE VIGNETTE Jim Mathis is a 45-year-old health-conscious man who has been a patient in an internal medicine–primary care practice for several years. At today’s visit, he talks about the family tree that he has sketched out and his discovery that three of his relatives had […]

Breast Cancer and Gene Mutations – Jeffery Bland, PhD – Video

2014 PLMI President Dr. Jeffrey Bland discusses a new editorial in the New England Journal of Medicine, “PALB2 Mutations and Breast Cancer Risk.” Evans MK, Longo DL.  PALB2 Mutations and Breast-Cancer Risk.  N Engl J Med 2014. 371;6:566-568. VIMEO Video

It’s Not Genes: People Are Fat Because They Eat Too Much – VIDEO

Arthur L. Caplan, PhD May 27, 2014 Story Source and Video Hi. I am Art Caplan, from the Division of Medical Ethics at the New York University Langone Medical Center in New York. Why are your patients fat? Why are people fat generally? Struggling with weight is a problem. I personally have done better with […]

The Biology and Genetics of Obesity — A Century of Inquiries

Perspective HISTORY OF MEDICINE Chin Jou, Ph.D. N Engl J Med 2014; 370:1874-1877May 15, 2014DOI: 10.1056/NEJMp1400613 The obese lack willpower; they overeat and underexercise — or so believe a majority of Americans. A 2012 online poll of 1143 adults conducted by Reuters and the market research firm Ipsos found that 61% of U.S. adults believed […]

Genes, Environment May Contribute Equally to Autism Risk

Medscape Medical News Norra MacReady May 05, 2014 In an analysis of more than 2 million families, genetics appeared to contribute 50% of the risk for an autism spectrum disorder (ASD), with environmental influences accounting for the remaining 50%, according to a report in an article publishedin the May 7 issue of JAMA. ASD risk increased as […]

Mother’s diet modifies her child’s DNA

29 April 2014 A mother’s diet before conception can permanently affect how her child’s genes function, according to a study published in Nature Communications. The first such evidence of the effect in humans opens up the possibility that a mother’s diet before pregnancy could permanently affect many aspects of her children’s lifelong health. Researchers from the […]

Dr. Dean Ornish: Your genes are not your fate – VIDEO

Published on Apr 24, 2014 http://www.ted.com Dr. Dean Ornish shares new research that shows how adopting healthy lifestyle habits can affect a person at a genetic level. For instance, he says, when you live healthier, eat better, exercise, and love more, your brain cells actually increase. And new findings show that a healthier lifestyle can turn off […]

Children’s genetic predisposition to mercury neurotoxicity

Genetic polymorphisms of catechol-o-methyltransferase modify the neurobehavioral effects of mercury in children. Woods JS, et al. J Toxicol Environ Health A. 2014;77(6):293-312. doi: 10.1080/15287394.2014.867210. Abstract Mercury (Hg) is neurotoxic and children may be particularly susceptible to this effect. A current major challenge is identification of children who may be uniquely susceptible to Hg toxicity because […]

Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women

American Heart Journal, 03/28/2014 Clinical Article Kalantarian S, et al. – Previous studies observed the surprising finding that saturated fat was inversely associated with atherosclerosis progression in postmenopausal women, whereas polyunsaturated fat (PUFA) and carbohydrates were positively associated. Whether certain genes modify the association of diet with atherosclerotic progression is unknown. The authors observed an […]

Fried Foods and Obesity: It’s Genetic

by Elizabeth DeVita Raeburn Contributing Writer, MedPage Today March 19, 2014 People with certain genes that predispose them to excess weight and obesity may be more susceptible to gaining weight from eating fried food, a study reports. In subjects in the highest third for genetic risk of obesity, the difference in body mass index (BMI) […]

Heart-Healthy Lifestyle Changes Also Alter Gene Expression

Marlene Busko March 05, 2014 WINDBER, PA — After a yearlong, intensive diet, exercise, and stress-management program to reduce cardiovascular risk factors, participants who successfully followed the program and lost weight also had positive changes at the molecular level, researchers report[1]. “What’s really new and important about this study is that throughout a year of lifestyle changes, […]

Meditation Alters Genes Rapidly, Triggers Molecular Changes

Elizabeth Renter Infowars.com January 30, 2014 Full Story Journal Reference If you are a practitioner of meditation, the results of a new study published in Psychoneuroendocrinology will likely come as no surprise. But for some scientists, the revelation that meditating can actually trigger molecular changes is groundbreaking. The researchers from the University of Wisconsin-Madison and the Institute of […]

For Better or Worse? Type 2 Diabetes Risk Shared in Marriage

Becky McCall January 27, 2014 Full Story Risk for type 2 diabetes is shared, with around a 20% increased risk for individuals whose partners have the disease, confirms a new study, whose authors suggest that behavioral and environmental factors might have a significant role to play. Findings of the systematic review and meta-analysis are published online January […]

Gout: The Risks Are Relative

Published: Nov 23, 2013 | Updated: Nov 25, 2013 Full Story:  http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/43087 By Nancy Walsh, Staff Writer, MedPage Today Action Points Gout does cluster within families, with increased risks being seen for individuals with affected close relatives. Note that heritability and familial transmission were both higher among men than women. Gout does cluster within families, […]

Exercise: Putting Action into Our Epigenome

Denham J,et al. Sports Med. 2013 Oct 27. [Epub ahead of print] Affiliation School of Health Sciences, Federation University Australia, Room 228, Y Building, University Drive, Mt Helen, Ballarat, VIC, 3350, Australia. Abstract Most human phenotypes are influenced by a combination of genomic and environmental factors. Engaging in regular physical exercise prevents many chronic diseases, […]

Investigators find gene influences risk of lumbar disc degeneration

October 21, 2013 A genetic variation found after searching the genome of families in China, Japan and Finland with a history of lumbar disc degeneration has been linked to an increased susceptibility to the disease, according to researchers from the University of Hong Kong. “Our finding provides a key functional link of this variant form […]

Effect of Comprehensive Lifestyle Changes on Telomerase Activity and Telomere Length in Men With Biopsy-Proven Low-Risk Prostate Cancer

5-Year Follow-Up of a Descriptive Pilot Study Lancet Oncol. 2013 Oct 01;14(11)1112-1120, D Ornish, J Lin, JM Chan, E Epel, C Kemp, G Weidner, R Marlin, SJ Frenda, MJ Magbanua, J Daubenmier, I Estay, NK Hills, N Chainani-Wu, PR Carroll, EH Blackburn TAKE-HOME MESSAGE Can lifestyle changes affect telomere length? Increased telomere length is associated […]