Disc Degeneration

Biomechanics of Degenerative Spinal Disorders

Asian Spine J. 2016 Apr; 10(2): 377–384. Published online 2016 Apr 15. doi:  10.4184/asj.2016.10.2.377 PMCID: PMC4843079 Justin A. Iorio,1 Andre M. Jakoi,2 and Anuj Singla3 Author information ► Article notes ► Copyright and License information ► Go to: Abstract The spine has several important functions including load transmission, permission of limited motion, and protection of […]

Progression of lumbar disc herniations over an eight-year period -a longitudinal MRI study using quantitative measures

BMC Musculoskelet Disord. 2016 Jan 15;17(1):26. doi: 10.1186/s12891-016-0865-6. Progression of lumbar disc herniations over an eight-year period in a group of adult Danes from the general population – a longitudinal MRI study using quantitative measures. Kjaer P, Tunset A, Boyle E, Jensen TS. Abstract BACKGROUND: A lumbar disc herniation (LDH) is a localised displacement of […]

MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls

AJNR Am J Neuroradiol. 2015 Dec;36(12):2394-9. doi: 10.3174/ajnr.A4498. Epub 2015 Sep 10. MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis. Brinjikji W, Diehn FE, Jarvik JG, Carr CM, Kallmes DF, Murad MH4 Luetmer PH. Abstract BACKGROUND AND PURPOSE: Imaging features of […]

Disc degeneration implies low back pain

Theor Biol Med Model. 2015 Nov 9;12(1):24. doi: 10.1186/s12976-015-0020-3. Zheng CJ, Chen J. Abstract BACKGROUND: Low back pain exerts a tremendous burden on individual patients and society due to its prevalence and ability to cause long-term disability. Contemporary treatment and prevention efforts are stymied by the absence of a confirmed cause for the majority of […]

Risk factors for lumbar intervertebral disc height narrowing: a population-based longitudinal study in the elderly

BMC Musculoskelet Disord. 2015 Nov 9;16(1):344. doi: 10.1186/s12891-015-0798-5. Akeda K, Yamada T, Inoue N, Nishimura A, Sudo A. Abstract BACKGROUND: The progression of disc degeneration is generally believed to be associated with low back pain and/or degenerative lumbar diseases, especially in the elderly. The purpose of this study was to quantitatively evaluate changes in lumbar […]

Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing: A Cross-Sectional MRI Study

Spine: November 2015 – Volume 40 – Issue 21 – p 1690–1696 Hansen, Bjarke B. MD Abstract Study Design. Cross-sectional study. Objective. To examine the influence of low-back pain (LBP) and lumbar disc degeneration (LDD) on the lumbar lordosis in weight-bearing positional magnetic resonance imaging (pMRI). Summary of Background Data. The lumbar lordosis increases with […]

Systematic literature review of imaging features of spinal degeneration in asymptomatic populations

AJNR Am J Neuroradiol. 2015 Apr;36(4):811-6. doi: 10.3174/ajnr.A4173. Epub 2014 Nov 27. Brinjikji W Abstract BACKGROUND AND PURPOSE: Degenerative changes are commonly found in spine imaging but often occur in pain-free individuals as well as those with back pain. We sought to estimate the prevalence, by age, of common degenerative spine conditions by performing a […]

Inflammation in intervertebral disc degeneration and regeneration – Full Text Article

Journal of the Royal Society Interface Maria Molinos, Catarina R. Almeida, Joana Caldeira, Carla Cunha, Raquel M. Gonçalves and Mário A. Barbosa Published:06 March 2015 https://doi.org/10.1098/rsif.2014.1191 Abstract Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as […]

Symptomatic versus Asymptomatic Intervertebral Disc Degeneration: Is Inflammation the Key?

Critical Reviews™ in Eukaryotic Gene Expression Volume 25, 2015 Issue 1 DOI: 10.1615/CritRevEukaryotGeneExpr.2015012369 pages 13-21 Yan Peng Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong Feng-Juan Lv Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong; HKU Shenzhen Institute of […]

Interrater and intrarater agreements of magnetic resonance imaging findings in the lumbar spine: significant variability across degenerative conditions.

Spine J. 2014 Oct 1;14(10):2442-8. doi: 10.1016/j.spinee.2014.03.010. Epub 2014 Mar 15. Fu MC1, Buerba RA1, Long WD 3rd1, Blizzard DJ2, Lischuk AW3, Haims AH3, Grauer JN4. Abstract BACKGROUND CONTEXT: Magnetic resonance imaging (MRI) is frequently used in the evaluation of degenerative conditions in the lumbar spine. The relative interrater and intrarater agreements of MRI findings […]

Determinants of evolution of endplate and disc degeneration in the lumbar spine: a multifactorial perspective

Eur Spine J. 2014 Sep;23(9):1863-8. doi: 10.1007/s00586-014-3382-z. Epub 2014 Jun 5. Farshad-Amacker NA1, Hughes AP, Aichmair A, Herzog RJ, Farshad M. Abstract PURPOSE: Evolution and progression of disc and endplate bone marrow degeneration of the lumbar spine are thought to be multifactorial, yet, their influence and interactions are not understood. The aim of this study […]

Short-Term Effect of Spinal Manipulation on Pain Perception, Spinal Mobility, and Full Height Recovery in Male Subjects With Degenerative Disk Disease: A Randomized Controlled Trial

VOLUME 95, ISSUE 9, P1613-1619, SEPTEMBER 2014 Felipe Vieira-Pellenz, PT, PhD Published: May 23, 2014 DOI:https://doi.org/10.1016/j.apmr.2014.05.002 Abstract Objective To evaluate the short-term effect on spinal mobility, pain perception, neural mechanosensitivity, and full height recovery after high-velocity, low-amplitude (HVLA) spinal manipulation (SM) in the lumbosacral joint (L5-S1). Design Randomized, double-blind, controlled clinical trial with evaluations at […]

Menopause is associated with lumbar disc degeneration: a review of 4230 intervertebral discs

Climacteric. 2014 Dec;17(6):700-4. doi: 10.3109/13697137.2014.933409. Epub 2014 Aug 17. Lou C, Chen HL, Feng XZ, Xiang GH, Zhu SP, Tian NF, Jin YL, Fang MQ, Wang C, Xu HZ. Abstract OBJECTIVE: The main objective of this study was to investigate, in a population of normal postmenopausal women, the association between menopause and severity of lumbar […]

Adolescent cervical disc degeneration in MRI does not predict adult headache or neck pain

Adolescent cervical disc degeneration in MRI does not predict adult headache or neck pain: A 5-year follow-up of adolescents with and without headache. Laimi K, et al. Cephalalgia. 2014. Abstract AIM: The impact of early degenerative changes of the cervical spine on pain in adulthood is unknown. The objective was to determine whether degeneration in […]

Effects of Spinal Stabilization Exercise on the Cross-sectional Areas of the Lumbar Multifidus and Psoas Major Muscles, Pain Intensity, and Lumbar Muscle Strength of Patients with Degenerative Disc Disease

J Phys Ther Sci. 2014 Apr;26(4):579-82. doi: 10.1589/jpts.26.579. Epub 2014 Apr 23. Kim S Abstract [Purpose] The aim of this study was to evaluate the efficacy of using spinal stabilizing exercise to reduce atrophy of the multifidus and psoas major muscles, reduce the levels of pain and disability, and increase paraspinal muscle strength in patients […]

Why do some intervertebral discs degenerate, when others (in the same spine) do not?

Clin Anat. 2015 Mar;28(2):195-204. doi: 10.1002/ca.22404. Epub 2014 Apr 19. Adams MA Abstract This review suggests why some discs degenerate rather than age normally. Intervertebral discs are avascular pads of fibrocartilage that allow movement between vertebral bodies. Human discs have a low cell density and a limited ability to adapt to mechanical demands. With increasing […]

Aging changes in lumbar discs and vertebrae and their interaction: a 15-year follow-up study

Spine J. 2014 Mar 1;14(3):469-78. doi: 10.1016/j.spinee.2013.11.018. Epub 2013 Nov 19. Tapio Videman Abstract Background context: Many studies have focused on either the intervertebral disc as a culprit in back pain problems, or the vertebral body, but very few studies have examined both structures and their relationship. Purpose: To measure the concordant changes in morphology […]

Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse magnetic resonance imaging analysis of 224 patients

The Spine Journal Volume 14, Issue 2, 1 February 2014, Pages 300–307 Rishi M. Kanna, MS, MRCS, FNB, Ajoy Prasad Shetty, MS, DNB, S. Rajasekaran, MS, MCh, FRCS(Ed), FRCS(London), FACS, PhD Abstract Background context Existing research on lumbar disc degeneration has remained inconclusive regarding its etiology, pathogenesis, symptomatology, prevention, and management. Degenerative disc disease (DDD) […]

Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse

Spine J. 2014 Feb 1;14(2):300-7. doi: 10.1016/j.spinee.2013.10.042. Epub 2013 Nov 12. Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse magnetic resonance imaging analysis of 224 patients. Kanna RM1, Shetty AP1, Rajasekaran S2. Abstract BACKGROUND CONTEXT: Existing research on lumbar disc degeneration has remained inconclusive regarding its etiology, pathogenesis, symptomatology, […]

Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study

Osteoarthritis Cartilage. 2014 Jan;22(1):104-10. doi: 10.1016/j.joca.2013.10.019. Epub 2013 Nov 14. Teraguchi M1, Yoshimura N2, Hashizume H3, Muraki S4, Yamada H1, Minamide A1, Oka H2, Ishimoto Y1, Nagata K1, Kagotani R1, Takiguchi N1, Akune T4,Kawaguchi H5, Nakamura K6, Yoshida M1. Abstract OBJECTIVES: The purposes of this study were to investigate the prevalence and distribution of intervertebral […]