Muscle Relaxants

Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review

Alice Baroncini, Nicola Maffulli, Hazim Al-Zyoud, Andreas Bell, Aleksandar Sevic, Filippo Migliorini First published: 22 February 2023 https://doi.org/10.1002/jor.25508 Abstract Acute low back pain (LBP) imposes a significant socioeconomical burden as it is the condition that, worldwide, cause the most disability. Nonetheless, the literature regarding the best pharmacological management of acute LBP is limited, and the […]

AMA Patient Page – Low Back Pain

AMA Patient Page July 20, 2021 Low Back Pain Adrian C. Traeger, PhD JAMA. 2021;326(3):286. doi:10.1001/jama.2020.19715 Journal Reference

Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis

BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1446 (Published 08 July 2021) Cite this as: BMJ 2021;374:n1446 Aidan G Cashin Abstract Objective To investigate the efficacy, acceptability, and safety of muscle relaxants for low back pain. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Medline, Embase, CINAHL, CENTRAL, ClinicalTrials.gov, clinicialtrialsregister.eu, and WHO ICTRP from inception to 23 February […]

Muscle Relaxer Rx Doubled Over 12-Year Span

— Spike in prescriptions among older adults particularly concerning, researchers note by Elizabeth Hlavinka, Staff Writer, MedPage Today June 24, 2020 As U.S. opioid prescriptions continue to trend downwards, skeletal muscle relaxer scripts are on the rise, according to an analysis of the CDC’s National Ambulatory Medical Care Survey (NAMCS). Between 2005 and 2016, the number […]

Study: Opioids, Muscle Relaxants Ineffective for Acute Low Back Pain

DECEMBER 04, 2015 Prescribing opioids and muscle relaxants to acute low back pain (LBP) patients who are already on nonsteroidal anti-inflammatory drugs (NSAIDs) does not provide additional pain relief, a new study suggests. There are more than 2.5 million acute LBP-related visits to emergency departments in the United States annually, where patients are often treated […]

Naproxen With Cyclobenzaprine or Oxycodone/Acetaminophen for Acute Low-Back Pain

October 28, 2015 JAMA : The Journal of the American Medical Association TAKE-HOME MESSAGE Patients with acute non-traumatic, non-radicular low-back pain for In patients presenting to the emergency department with acute low-back pain, the addition of cyclobenzaprine or oxycodone/acetaminophen to naproxen had no clinical benefit over naproxen alone. Primary Care Written by David Rakel MD, […]

Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain

A Randomized Clinical Trial October 20, 2015 Benjamin W. Friedman, MD, MS Importance Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination. Objective To compare functional outcomes and […]

Drugs for relief of pain in patients with sciatica

Systematic review and meta-analysis Rafael Zambelli Pinto, PhD student BMJ 2012; 344 doi: http://dx.doi.org/10.1136/bmj.e497 (Published 13 February 2012) Cite this as: BMJ 2012;344:e497 Abstract Objective To investigate the efficacy and tolerability of analgesic and adjuvant pain drugs typically administered in primary care for the management of patients with sciatica. Design Systematic review. Data source International […]

A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain

T. Kuijpers European Spine Journal January 2011, Volume 20, Issue 1, pp 40-50 First online: 31 July 2010 Abstract The objective of this review was to determine the effectiveness of pharmacological interventions [i.e., non-steroid anti-inflammatory drugs (NSAIDs), muscle relaxants, antidepressants, and opioids] for non-specific chronic low-back pain (LBP). Existing Cochrane reviews for the four interventions […]