Drugs

Prenatal Acetaminophen Use Linked to Poorer Early Language Development

Primary Care News · January 08, 2024 Prenatal Acetaminophen Use Linked to Poorer Early Language Development Third-trimester use linked to poorer language outcomes among male children FRIDAY, Jan. 5, 2024 (HealthDay News) — Prenatal acetaminophen use during pregnancy is associated with poorer early language development, especially among male offspring, according to a study published online […]

The Role of Systemic Steroids in Sciatica Due to Herniated Lumbar Disc

A Systematic Review and Meta-analysis Vale, João MDa; Rocha, Eduardo MDb; Lemos, Carolina MD, PhDc,d; Valente, Cristina PhDe,f; Andrade, Renato BSce,f,g; Espregueira-Mendes, João MD, PhDe,f,h,i,,j; Rodrigues-Pinto, Ricardo MD, PhD, FEBOTa,c,k Spine 48(23):p E391-E400, December 1, 2023. | DOI: 10.1097/BRS.0000000000004801 Abstract Study Design. Systematic review and meta-analysis. Objective. Evaluate the role of systemic steroids in treating […]

For Tension Headache, Combo Rx Tops Acetaminophen

December 1, 2014 Alisa G. Woods, PhD Pain relief is better with a triple combination medication that includes acetaminophen than with acetaminophen by itself, researchers found, suggesting a new therapeutic option. A triple combination medication for tension headache that includes acetaminophen is more effective for pain relief than acetaminophen by itself, an international group of […]

Cannabis Use Disorder Tied to Incident Cardiovascular Disease Events

October 14, 2023 Higher risk for incident events seen over seven years of follow-up THURSDAY, Oct. 12, 2023 (HealthDay News) — Adults with cannabis use disorder (CUD) have a higher risk for incident adverse cardiovascular disease (CVD) events when compared with matched adults without CUD, according to a study published online Sept. 27 in Addiction. […]

Safety, Efficacy, and Tolerability of the Modified Atkins Diet in Persons With Drug-Resistant Epilepsy

April 06, 2023 TAKE-HOME MESSAGE This randomized controlled trial compared the efficacy of the modified Atkins diet (a more liberal ketogenic diet that is presumed to have greater adherence rates) plus standard drug therapy with that of standard drug therapy alone in patients with drug-resistant epilepsy. Although the study included only 160 patients, the dietary […]

Recreational Cannabis Use a Negative for Adolescent Mental Health

— Even “subdiagnostic” use associated with adverse psychological events, study says by Elizabeth Short, Staff Writer, MedPage Today May 4, 2023 Cannabis use that doesn’t rise to the level of diagnosable substance abuse disorder was nonetheless associated with negative affects on mental health, national data showed. In the 2015 to 2019 National Surveys on Drug […]

Overprescribed Antibiotics for Colds Causes Patient Harm

April 30, 2023 Researchers identify hundreds of thousands of cases of resulting diarrhea, candidiasis, and Clostridium difficile infections needing medical attention THURSDAY, April 27, 2023 (HealthDay News) — Overprescribing of antibiotics for acute upper respiratory infections (aURIs) causes significant patient harm, according to a study published in the April issue of the Journal of Internal […]

A Systematic Review of Clinical Practice Guidelines for Persons With Non-specific Low Back Pain With and Without Radiculopathy: Identification of Best Evidence for Rehabilitation to Develop the WHO’s Package of Interventions for Rehabilitation

Arch Phys Med Rehabil. 2023 Mar 23;S0003-9993(23)00160-0. doi: 10.1016/j.apmr.2023.02.022. Fabio Zaina PMID: 36963709 DOI: 10.1016/j.apmr.2023.02.022 Abstract Objective: To Identify evidence-based rehabilitation interventions for persons with non-specific low back pain (LBP) with and without radiculopathy and to develop recommendations from high-quality clinical practice guidelines (CPGs) to inform the World Health Organization’s (WHO) Package of Interventions for […]

Docs’ Liking for Knee Injection Tied to Industry Payments

— Threefold rate for giving hyaluronic acid shots among those paid more than $100 by John Gever, Contributing Writer, MedPage Today March 20, 2023 Physicians accepting payments from drug and device companies administered significantly more hyaluronic acid (HA) injections to Medicare beneficiaries for knee osteoarthritis, researchers found. Those receiving more than $100 in cash or […]

Long-term, systemic antibiotic use for the treatment of adolescent acne can promote fat accumulation

Long-term, systemic antibiotic use for the treatment of adolescent acne can promote fat accumulation Published March 14, 2023 | Originally published on MedicalXpress Breaking News-and-Events A growing body of evidence is showing that the healthy gut microbiome—a community of microorganisms that live together in the gut—influences many aspects of human growth and development, especially during […]

Regular Use of Laxatives Linked to Risk for All-Cause Dementia

February 27, 2023 Risk for all-cause, vascular dementia was increased with number of regularly used laxative types THURSDAY, Feb. 23, 2023 (HealthDay News) — Regular use of laxatives, especially use of multiple laxative types, is associated with an increased risk for all-cause dementia, according to a study published online Feb. 22 in Neurology. Zhirong Yang, […]

Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review

Alice Baroncini, Nicola Maffulli, Hazim Al-Zyoud, Andreas Bell, Aleksandar Sevic, Filippo Migliorini First published: 22 February 2023 https://doi.org/10.1002/jor.25508 Abstract Acute low back pain (LBP) imposes a significant socioeconomical burden as it is the condition that, worldwide, cause the most disability. Nonetheless, the literature regarding the best pharmacological management of acute LBP is limited, and the […]

Effect of Statin Therapy on Muscle Symptoms

September 14, 2022 The Lancet TAKE-HOME MESSAGE This large meta-analysis investigated the effects of statins on muscle symptoms over time based on data from 154,664 participants in 23 double-blind trials. The relative increase of muscle pain or weakness was <10% (1 in 15 patients), mainly during the first year of statin use. It also confirmed […]

What is long-term cannabis use doing to our brains?

By Joe Hannan | Medically reviewed by Amanda Zeglis, DO, MBA | Published August 17, 2022 Key Takeaways A 2022 study found that long-term cannabis users had cognitive deficits and lower hippocampal volume at age 45 compared with non-users and users of other substances. Legalization and decriminalization efforts, coupled with medical marijuana programs, may be […]

Initial Choice of Spinal Manipulation Reduces Escalation of Care for Chronic Low Back Pain Among Older Medicare Beneficiaries

Whedon, James M. DC, MS SPINE: February 15, 2022 – Volume 47 – Issue 4 – p E142-E148 doi: 10.1097/BRS.0000000000004118 Study Design. We combined elements of cohort and crossover-cohort design. Objective. The objective of this study was to compare longterm outcomes for spinal manipulative therapy (SMT) and opioid analgesic therapy (OAT) regarding escalation of care […]

Regular Acetaminophen Use and Blood Pressure in People With Hypertension

Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial Iain M. MacIntyre, Emma J. Turtle, Tariq E. Farrah, Catriona Graham, James W. Dear and David J. Webb and for the PATH-BP (Paracetamol in Hypertension–Blood Pressure) Investigators* Originally published 7 Feb 2022https://doi.org/10.1161/CIRCULATIONAHA.121.056015Circulation. 2022;145:416–423 Abstract Background: Acetaminophen is widely used as first-line therapy […]

Cost Study Backs PT Over Steroid Shots in Knee Osteoarthritis

— Better efficacy and no pricier over time by John Gever, Contributing Writer, MedPage Today January 24, 2022 Although physical therapy for osteoarthritis of the knee costs more than an intra-articular steroid injection, it’s cost-effective when clinical outcomes a year later are taken into account, researchers said. A secondary analysis of data from 156 participants […]

Local Steroid Injection for Carpal Tunnel Syndrome

November 10, 2021 JAMA Network Open TAKE-HOME MESSAGE This follow-up to a double-blind, placebo-controlled RCT sought to explore whether local steroid injection (with 80 mg or 40 mg of methylprednisolone) versus saline impacted long-term carpal tunnel pain scores and rates of carpal tunnel release surgery, as well as other outcomes such as time to surgery. The […]

Topical Anti-Inflammatory Effective For Knee Osteoarthritis

November 07, 2021 BMJ : British Medical Journal TAKE-HOME MESSAGE This comprehensive systematic review and network meta-analysis assesses the efficacy and safety of multiple preparations and doses of NSAIDs, opioids, and acetaminophen for clinically relevant reductions in pain caused by knee and hip osteoarthritis. The review includes nearly 200 randomized controlled trials comprised of over 100,000 […]

Daily use of cannabidiol (‘CBD’) oil may be linked to lung cancer regression

Newswise: Respiratory Diseases and Disorders | October 15, 2021 It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung cancer treatment, suggest doctors in BMJ Case Reports after dealing with a daily user whose lung tumour shrank without the aid of conventional treatment. The body’s own endocannabinoids are involved […]