April 29, 2024 Adjusted odds ratios of 1.70, 1.40, and 1.30 seen for proton pump inhibitors, H2 receptor antagonists, and generic antacids, respectively FRIDAY, April 26, 2024 (HealthDay News) — Use of acid-suppression therapy is associated with higher odds of migraine or severe headache, according to a study published online April 24 in Neurology: Clinical Practice. […]
Journal of Gastroenterology and Hepatology — Jiang K, et al. | October 30, 2019 Via performing systematical analysis, researchers sought to ascertain how long-term therapy with proton pump inhibitors (PPIs) influence the risk of gastric cancer. Seven relevant articles with 943,070 patients were included in this work. The analysis revealed that the risk of gastric […]
MedicalXpress Breaking News-and-Events | June 07, 2019 People who use common heartburn drugs for months to years may face heightened risks of dying from heart disease, kidney failure or stomach cancer, a new study suggests. The study included more than 200,000 US veterans. It’s the latest to raise concerns over drugs called proton pump inhibitors […]
April 19, 2018 JAMA Pediatrics TAKE-HOME MESSAGE A large cohort of 792,130 children was retrospectively assessed to evaluate the association between exposure to acid-suppressive medications and antibiotics in the first 6 months of life and the risk of allergic diseases in early childhood. Histamine-2 receptor antagonists (H2RAs) were prescribed for 7.6% of children, while 1.7% […]
MARCH 09, 2018 Top News in Neurology Healthline/Medical News Today A new study—now published in the journal Psychotherapy and Psychosomatics—has found a link between a common class of stomach drugs called proton pump inhibitors and depression. The researchers suggest that the pills might lead to major depressive disorder by disrupting the gut’s bacteria. More and more […]
January 24, 2018 Pediatrics TAKE-HOME MESSAGE The authors of this systematic review of eight population-based studies evaluated the association between use of acid-suppressive drugs in pregnancy and the risk of childhood asthma in the offspring. The relative risk of asthma in childhood was 1.45 for those using acid-suppressive drugs in pregnancy compared with no use […]
NOVEMBER 10, 2017 Top News in Family Medicine University College London News The long term use of proton pump inhibitors (PPIs), a class of drugs commonly used to treat acid reflux, is linked to a more than doubling in the risk of developing stomach cancer, finds research by UCL and The University of Hong Kong. […]
BMJ Open | October 31, 2017 Brusselaers N, et al. – In Sweden, a nationwide population-based cohort study is performed to evaluate the risk of gastric cancer-related to proton pump inhibitor (PPI) use, considering underlying signs. The outcome suggests that the long-term PPI use might be an independent risk factor for gastric cancer. This challenges […]
Patients who take proton pump inhibitors for a year or more have an increased risk for death, according to a new study. JULY 7, 2017 Popular Heartburn Drugs Linked to Higher Death By PPN News Staff Proton pump inhibitors (PPIs) have been linked to a variety of health problems, including serious kidney damage, bone fractures and […]
News | July 06, 2017 | Alzheimer disease By Felicia C. Goldstein, PhD and Heidi Anne Duerr, MPH Dr Goldstein is Professor in the department of neurology at Emory University School of Medicine. Following last year’s study in JAMA Neurology, which linked proton pump inhibitors (PPIs) with cognitive decline and dementia, patients and clinicians grew concerned about […]
Al Saint Jacques, MDLinx Study authors have shown that taking popular proton pump inhibitors (PPIs) for heartburn for prolonged periods has been linked to serious kidney problems, including kidney failure, according to a study published in the February 22 issues of the journal Kidney International. In many cases, the sudden onset of kidney problems serves […]
February 07, 2017 PloS One TAKE-HOME MESSAGE No association between the use of proton pump inhibitors (PPIs) and reduced risk for esophageal adenocarcinoma and high-grade dysplasia in patients with Barrett’s esophagus was found in an analysis of nine observational studies. Nor was a duration–response relationship noted. PPIs were not found to provide any significant protection […]
June 10, 2016 PPI users have reduced mean femoral T-scores, increased frequency of osteoporosis, osteopenia WEDNESDAY, June 8, 2016 (HealthDay News) — Proton pump inhibitor (PPI) use is associated with increased risk of developing osteoporosis and osteopenia in femur bones, according to a study published online May 31 in the International Journal of Rheumatic Diseases. […]
May 30, 2016 Increased risk of small bowel injury for healthy participants treated with celecoxib + PPI HealthDay FRIDAY, May 27, 2016 (HealthDay News) — Proton pump inhibitors (PPIs) increase the risk of nonsteroidal anti-inflammatory drug-induced small bowel injury, according to a study published in the June issue of Clinical Gastroenterology and Hepatology. Ema Washio, […]
May 10, 2016 HealthDay ReporterTUESDAY, May 10, 2016 (HealthDay News) — A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say. Faster aging of blood vessel cells exposed to the antacid Nexium (esomeprazole) might potentially hinder the tasks these […]
02.15.2016 German claims data show association; stronger in men than women by Kristina Fiore Associate Editor, MedPage Today Proton pump inhibitors (PPIs) were associated with an increased risk of dementia, and the relationship was stronger in men than women, according to a study of German medical claims data. In an assessment of data from the […]
Marcia Frellick November 12, 2015 Proton-pump inhibitors are commonly used in hospitals to prevent gastrointestinal (GI) bleeding, but may increase the risk of dying both for those who start use in the hospital and for those have used them before admission and continue use in the hospital, new data show. Matt Pappas, MD, MPH, from […]
4/2/15 by Salynn Boyles Action Points Mouse studies may help explain the reported increased risk of osteoporosis and related fractures among long-term users of proton pump inhibitors, which are among the most widely used drugs on the planet. Note that the research showed that stomach acid helps the intestines absorb and transfer calcium to the […]
JAMA internal medicine TAKE-HOME MESSAGE Researchers retrospectively evaluated 754 patients with healthcare-associated Clostridium difficile infection to determine the association of proton pump inhibitor use (PPI) with recurrence. The hazard ratio for recurrence was 1.5 for continuous PPI use, and 47.1% of patients receiving PPIs had an evidence-based indication. Researchers suggest that PPI use without proper […]
Circulation, 08/20/2013 Exclusive Author Commentary Clinical Article Ghebremariam YT et al. – Proton pump inhibitors (PPIs) are gastric acid–suppressing agents widely prescribed for the treatment of gastroesophageal reflux disease. Recently, several studies in patients with acute coronary syndrome have raised the concern that use of PPIs in these patients may increase their risk of major […]