Drugs

Topical Anti-Inflammatory Effective For Knee Osteoarthritis

November 07, 2021 BMJ : British Medical Journal TAKE-HOME MESSAGE This comprehensive systematic review and network meta-analysis assesses the efficacy and safety of multiple preparations and doses of NSAIDs, opioids, and acetaminophen for clinically relevant reductions in pain caused by knee and hip osteoarthritis. The review includes nearly 200 randomized controlled trials comprised of over 100,000 […]

Daily use of cannabidiol (‘CBD’) oil may be linked to lung cancer regression

Newswise: Respiratory Diseases and Disorders | October 15, 2021 It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung cancer treatment, suggest doctors in BMJ Case Reports after dealing with a daily user whose lung tumour shrank without the aid of conventional treatment. The body’s own endocannabinoids are involved […]

Safety risk associated with use of nonsteroidal anti-inflammatory drugs in Japanese elderly compared with younger patients with osteoarthritis and/or chronic low back pain: A retrospective database study

Kanae Togo PhD,Nozomi Ebata PhD,Naohiro Yonemoto PhD,Lucy Abraham MSc CPsychol, First published: 19 September 2021 https://doi.org/10.1111/papr.13079 Abstract Purpose This study aimed to assess the safety risks associated with using nonsteroidal anti-inflammatory drugs (NSAIDs) in elderly patients (≥65 years) compared with younger patients (<65 years) with osteoarthritis (OA) and/or chronic low back pain (CLBP). Methods A retrospective analysis […]

AMA Patient Page – Low Back Pain

AMA Patient Page July 20, 2021 Low Back Pain Adrian C. Traeger, PhD JAMA. 2021;326(3):286. doi:10.1001/jama.2020.19715 Journal Reference

Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis

BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1446 (Published 08 July 2021) Cite this as: BMJ 2021;374:n1446 Aidan G Cashin Abstract Objective To investigate the efficacy, acceptability, and safety of muscle relaxants for low back pain. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Medline, Embase, CINAHL, CENTRAL, ClinicalTrials.gov, clinicialtrialsregister.eu, and WHO ICTRP from inception to 23 February […]

A user’s guide to over-the-counter analgesics like acetaminophen, ibuprofen, and more

The Science of Pain-Killers A user’s guide to over-the-counter analgesics like acetaminophen, ibuprofen, and more Paul Ingraham • Jun 30, 2021 • 15m read Ordinary pain-killers like ibuprofen and acetaminophen are fairly safe and somewhat effective in moderation and work in different ways, so cautious experimentation is justified for many people. They are all roughly […]

Research shows pain relieving effects of CBD

Date:  April 25, 2021 Source:  Syracuse University Summary:  In an experimental pain study of CBD in humans, researchers conclude that CBD pain relief is driven by both pharmacological action and psychological placebo effects. It’s been hailed as a wonder drug and it’s certainly creating wonder profits. By some estimates, the Cannabidiol (or CBD) market could […]

Common blood pressure medications linked to increased skin cancer risk

Reuters Health Medical News|April 13, 2021 Thiazide diuretics, which are used by many older patients to control blood pressure, are linked to increased risk of certain skin cancers in a new Canadian study. The analysis of data from more than 300,000 Ontario adults aged 66 and older revealed that prolonged use of thiazides, including hydrochlorothiazide, […]

Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis

Gianola S, Bargeri S, Del Castillo G, et al British Journal of Sports Medicine Published Online First: 13 April 2021. doi: 10.1136/bjsports-2020-103596 Abstract Objective To assess the effectiveness of interventions for acute and subacute non-specific low back pain (NS-LBP) based on pain and disability outcomes. Design A systematic review of the literature with network meta-analysis. Data sources Medline, […]

Aspirin use and misuse for the primary prevention of cardiovascular diseases

Luepker RV, Oldenburg NC, Misialek JR, et al American Journal of Preventive Medicine | February 4, 2021 This study was sought to present the prevalence of appropriate aspirin use and physician advice in a population sample using the Task Force recommendations. Between 2017 and 2018, a random sample of men and women (aged 50–69 years) […]

4 unintended consequences of antibiotic use

Naveed Saleh, MD, MS | January 8, 2021 In recent years, the gut microbiome has received much attention. The microbiota plays an important role in health and pathology. Hard-to-treat nosocomial infections in hospitalized patients, for instance, often derive from the microbiome, where antibiotic use selects for antibiotic-resistant organisms. Antibiotic use should always be carefully considered, […]

Long-Term Oral Bisphosphonates Get Little Love in Study

— Study compared hip fractures after 5 years, 7 years, and 10 years by Kristen Monaco, Staff Writer, MedPage Today December 7, 2020 Women got no extra protection against hip fracture from staying on oral bisphosphonates beyond 7 years, researchers reported. In a retrospective cohort study of nearly 30,000 women who completed 5 years of […]

Antibiotics Before Age 2 Associated With Chronic Childhood Health Problems

By MAYO CLINIC NOVEMBER 15, 2020 In a retrospective case study, Mayo Clinic researchers have found that antibiotics administered to children younger than 2 are associated with several ongoing illnesses or conditions, ranging from allergies to obesity. The findings appear in Mayo Clinic Proceedings. Using health record data from the Rochester Epidemiology Project, a population-based research […]

ACR 2020: Corticosteroid Injections Do Not Hasten Progression of Knee Osteoarthritis

November 9, 2020—It does not appear that corticosteroid injections for the management of pain associated with knee osteoarthritis contribute to worsening of the condition, according to research presented at the American College of Rheumatology Virtual Convergence 2020, which took place online from November 5 to 9. “Cortisone injections have been used for a long time […]

Epidural Corticosteroid Injections for Sciatica

An Abridged Cochrane Systematic Review and Meta-Analysis Oliveira, Crystian B. PhD SPINE: November 1, 2020 – Volume 45 – Issue 21 – p E1405-E1415 doi: 10.1097/BRS.0000000000003651 Study Design. Systematic with meta-analysis Objectives. The aim of this study was to investigate the efficacy and safety of epidural corticosteroid injections compared with placebo injection in reducing leg […]

Beta blockers may raise heart failure risk in women

Reuters Health Medical News|July 14, 2020 Among women with no prior history of cardiovascular disease, taking beta blockers for hypertension raises the risk of heart failure, a new study suggests. Among thousands of patients presenting to the hospital with acute coronary syndrome, more women taking beta blockers (21.3%) than men (16.7%) had heart failure, translating […]

Sobering Data on Risks of Short-Term Oral Corticosteroids

Sobering Data on Risks of Short-Term Oral Corticosteroids — Short steroid bursts linked to serious adverse events within a month by Nicole Lou, Staff Writer, MedPage Today July 6, 2020 Corticosteroid bursts as short as 2 weeks or less were still linked to severe adverse events among relatively healthy users, according to a large study […]

Muscle Relaxer Rx Doubled Over 12-Year Span

— Spike in prescriptions among older adults particularly concerning, researchers note by Elizabeth Hlavinka, Staff Writer, MedPage Today June 24, 2020 As U.S. opioid prescriptions continue to trend downwards, skeletal muscle relaxer scripts are on the rise, according to an analysis of the CDC’s National Ambulatory Medical Care Survey (NAMCS). Between 2005 and 2016, the number […]

Hormone replacement therapy, breast cancer risk factors, and breast cancer risk: A nationwide population-based cohort

Yoo TK, Han KD, Kim DH, et al Cancer Epidemiology, Biomarkers & Prevention|June 1, 2020 A nationwide cohort with risk stratification according to risk factors for breast cancer was examined for the association between hormone replacement therapy (HRT) and breast cancer. Data from 4,558,376 postmenopausal women who underwent breast cancer screening and regular health checkups […]

Efficacy of intra-articular hypertonic dextrose (prolotherapy) for knee osteoarthritis: A randomized controlled trial – Full Text Article

Sit RWS, Wu RWK, Rabago D Annals of Family Medicine|May 21, 2020 Researchers investigated whether intra-articular hypertonic dextrose prolotherapy (DPT) affords an efficacious option relative to normal saline (NS) injection for the management of knee osteoarthritis (KOA), via this single-center, parallel-group, blinded, randomized controlled trial at a university primary care clinic in Hong Kong. They […]