Drugs

Ditch the statins: 7 natural ways to lower your cholesterol levels

May 13, 2020 Naveed Saleh, MD, MS, for MDLinx Although statins are remarkably effective at lowering lipid levels, they have been mired in controversy, an imbroglio commonly referred to as the “statin wars.” Much of this controversy centers on the benefits of statins as primary prevention vs their adverse effects, most disconcertingly acute renal failure […]

Effect of Postoperative Nonsteroidal Anti-inflammatory Drugs on Nonunion Rates in Long Bone Fractures

William A. Tucker, MD; Mitchell C. Birt, MD; Archie A. Heddings, MD; Greg A. Horton, MD Orthopedics. https://doi.org/10.3928/01477447-20200428-06 Posted May 7, 2020 Abstract The association of nonsteroidal anti-inflammatory drugs (NSAIDs) with non-union in long bone fractures has been controversial. The purpose of this study was to evaluate whether NSAID exposure results in increased risk of […]

Impact of Chiropractic Care on Use of Prescription Opioids in Patients with Spinal Pain

James M Whedon, DC, MS Pain Medicine, pnaa014, https://doi.org/10.1093/pm/pnaa014 Published: 06 March 2020 Abstract Objective Utilization of nonpharmacological pain management may prevent unnecessary use of opioids. Our objective was to evaluate the impact of chiropractic utilization upon use of prescription opioids among patients with spinal pain. Design and Setting We employed a retrospective cohort design for […]

Impact of Chiropractic Care on Use of Prescription Opioids in Patients with Spinal Pain

James M Whedon, DC, MS Pain Medicine, pnaa014, https://doi.org/10.1093/pm/pnaa014 Published: 06 March 2020 Abstract Objective Utilization of nonpharmacological pain management may prevent unnecessary use of opioids. Our objective was to evaluate the impact of chiropractic utilization upon use of prescription opioids among patients with spinal pain. Design and Setting We employed a retrospective cohort design […]

Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis

Atherosclerosis — Kennedy C, et al. | March 12, 2020 Researchers performed this systematic review to determine if treatment with Coenzyme Q10 (CoQ10) can successfully improve symptoms and can ensure maintenance on statin therapy among patients with statin-associated myalgia. They analyzed relevant studies identified from MEDLINE, EMBASE and the Cochrane Library. For review, 8 studies […]

Cannabis Satisfaction High Despite Little Change in Pain Scores

— Better sleep may be driving satisfaction in chronic pain patients, study suggests by Judy George, Senior Staff Writer, MedPage Today March 3, 2020 NATIONAL HARBOR, Md. — Chronic pain patients expressed high satisfaction with medical cannabis despite clinically insignificant changes in pain scores, a prospective study showed. Of a subset of chronic pain patients […]

Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

BMJ Open — Barker AL, Soh SE, Sanders KM, et al. | February 25, 2020 A systematic review and exploratory meta-analysis of observational studies were conducted to provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. A systematic review […]

Aspirin for primary prevention of cardiovascular disease: A meta-analysis with a particular focus on subgroups

BMC Medicine — Gelbenegger G, Postula M, Pecen L, et al. | November 14, 2019 Thirteen randomized, controlled trials on the effect of aspirin for primary prevention of CVD vs control were included in this meta-analysis to examine the benefit-risk ratio of aspirin for primary prevention of CVD with a special focus on subgroups. Researchers […]

Relationship between long-term use of proton pump inhibitors and risk of gastric cancer: A systematic analysis

Journal of Gastroenterology and Hepatology — Jiang K, et al. | October 30, 2019 Via performing systematical analysis, researchers sought to ascertain how long-term therapy with proton pump inhibitors (PPIs) influence the risk of gastric cancer. Seven relevant articles with 943,070 patients were included in this work. The analysis revealed that the risk of gastric […]

Most toothaches do not require antibiotics, new ADA guideline says

October 29, 2019 Antibiotics are not needed for most toothaches, the American Dental Association, or ADA, instructed in a newly published guideline, saying that antibiotics may do more harm than good in these cases. Previous research has shown that dentists prescribe around 10% of all antibiotics, and that most are unnecessary. Such overprescribing can contribute to […]

Early Access to Chiropractors, PTs Tied to Decreased Long-Term Opioid Use

October 23, 2019 Odds of short- or long-term opioid use higher for initial visits with physicians for low back pain TUESDAY, Oct. 22, 2019 (HealthDay News) — Patients who initially see a physical therapist or chiropractor for low back pain rather than a primary care physician are much less likely to be prescribed opioids, according […]

A Warning From a Doctor Who Has Done Thousands of Steroid Injections for Arthritis

The extremely common treatment might be causing more harm than previously thought. JAMES HAMBLIN OCTOBER 17, 2019 After giving birth to a baby, a young woman told her nurses at Boston Medical Center that she was having pain in her hip. That happens sometimes after births, says Ali Guermazi, one of the doctors involved. As […]

Association Between Chiropractic Use and Opioid Receipt Among Patients with Spinal Pain: A Systematic Review and Meta-analysis

Pain Medicine, pnz219, https://doi.org/10.1093/pm/pnz219 Kelsey L Corcoran, DC Published:  27 September 2019 Abstract Objective To investigate the current evidence to determine if there is an association between chiropractic use and opioid receipt. Design Systematic review and meta-analysis. Methods The protocol for this review was registered on PROSPERO (CRD42018095128). The MEDLINE, PubMed, EMBASE, AMED, CINAHL, and Web of […]

Observational retrospective study of the association of initial healthcare provider for new-onset low back pain with early and long-term opioid use – Full Text

BMJ Open 2019;9:e028633. doi: 10.1136/bmjopen-2018-028633 First published September 20, 2019. Lewis E Kazis1, Omid Ameli1,2, James Rothendler1, Brigid Garrity1, Howard Cabral3, Christine McDonough4, Kathleen Carey1, Michael Stein1, Darshak Sanghavi2, David Elton5, Julie Fritz6, Robert Saper7 Abstract Objective This study examined the association of initial provider treatment with early and long-term opioid use in a national […]

Opioid Use Among Veterans of Recent Wars Receiving Veterans Affairs Chiropractic Care

Pain Med. 2018 Sep 1;19(suppl_1):S54-S60. doi: 10.1093/pm/pny114. Lisi AJ Abstract OBJECTIVE: To examine patient sociodemographic and clinical characteristics associated with opioid use among Veterans of Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) who receive chiropractic care, and to explore the relationship between timing of a chiropractic visit and receipt of an opioid prescription. METHODS: Cross-sectional analysis […]

Immune Responses Regulated by Cannabidiol

Cannabis and Cannabinoid Research James M. Nichols and Barbara L.F. Kaplan Published Online:4 Sep 2019 https://doi.org/10.1089/can.2018.0073 Abstract Introduction: Cannabidiol (CBD) as Epidiolex® (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance […]

Opioid usage patterns, patient characteristics, and the role of chiropractic services in a publicly funded inner city health care facility

Steven Passmore DC, PhD The Spine Journal Volume 19, Issue 9, Supplement, September 2019, Pages S78-S79 BACKGROUND CONTEXT Opioid prescription for spinal pain while common, is no longer recommended by recent clinical practice guidelines. Opioid prescription rates in the US and Canada are double those in most European countries. A recent study found chiropractic care […]

Paracetamol is ineffective for acute low back pain even for patients who comply with treatment

PAIN: August 23, 2019 – Volume Articles in Press – Issue – p doi: 10.1097/j.pain.0000000000001685 Abstract In 2014, the Paracetamol for Acute Low Back Pain (PACE) trial demonstrated that paracetamol had no effect compared with placebo in acute low back pain (LBP). However, noncompliance was a potential limitation of this trial. The aim of this study was to investigate the efficacy of paracetamol in acute […]

Do antidepressants work better than placebo?

Do antidepressants work better than placebo? Published Thursday 18 July 2019 By Tim Newman Scientists have been debating the efficacy of antidepressants for decades. The latest paper to throw its hat into the ring concludes that there is little evidence to show that they perform better than placebos. In 2017, around 17.3 million adults in the United […]

Effectiveness of Foot Orthoses Versus Corticosteroid Injection for Plantar Heel Pain: The SOOTHE Randomized Clinical Trial

Published: Journal of Orthopaedic & Sports Physical Therapy, 2019 Volume:49 Issue:7 Pages:491–500 DOI: 10.2519/jospt.2019.8807 Background Plantar heel pain is a common foot complaint that causes significant disability and poorer health-related quality of life. Foot orthoses and corticosteroid injection are effective treatments for plantar heel pain; however, it is unclear whether one is more effective than […]