Coenzyme Q10

Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-A meta-analysis

Sazali S, Badrin S, Norhayati MN, et al. BMJ Open | January 6, 2021 In adult patients with migraine, researchers determined the impacts of coenzyme Q10 (CoQ10), also known as ubiquinone, in reducing the severity and frequency of migraine attacks and the duration of headache in this systematic review and meta-analysis involving 371 participants. This […]

Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis

Atherosclerosis — Kennedy C, et al. | March 12, 2020 Researchers performed this systematic review to determine if treatment with Coenzyme Q10 (CoQ10) can successfully improve symptoms and can ensure maintenance on statin therapy among patients with statin-associated myalgia. They analyzed relevant studies identified from MEDLINE, EMBASE and the Cochrane Library. For review, 8 studies […]

Dietary natural products as emerging lipoprotein(a)-lowering agents

J Cell Physiol. 2019 Aug;234(8):12581-12594. doi: 10.1002/jcp.28134. Epub 2019 Jan 13. Dietary natural products as emerging lipoprotein(a)-lowering agents Amir Abbas Momtazi-Borojeni PMID: 30637725 DOI: 10.1002/jcp.28134 Abstract Elevated plasma lipoprotein(a) (Lp(a)) levels are associated with an increased risk of cardiovascular disease (CVD). Hitherto, niacin has been the drug of choice to reduce elevated Lp(a) levels in […]

Efficacy of CoQ10 as supplementation for migraine: A meta-analysis

Acta Neurologica Scandinavica — Zeng Z, et al. | November 19, 2018 In this first-in-kind study, researchers investigated the clinical utility of coenzyme Q10 (CoQ10), a nutritional agent, as a supplemental agent in migraine. Researchers searched Web of Science, PubMed, and Cochrane Library databases for potential articles evaluating the effects of CoQ10 on migraine. Two […]

Fibromyalgia Symptoms Improve With CoQ10 Supplementation

– Clinically significant improvement in various items from the Symptom Checklist-90-R FRIDAY, Jan. 6, 2017 (HealthDay News) — For patients with fibromyalgia (FM), coenzyme Q10(CoQ10) supplementation is associated with improvement in clinical symptoms, according to a letter to the editor published online Jan. 4 in CNS Neuroscience & Therapeutics. Elísabet Alcocer-Gómez, from the University of Sevilla […]

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

J Am Coll Nutr. 2016 May-Jun;35(4):346-53. doi: 10.1080/07315724.2015.1021057. Epub 2015 Jul 9. Farsi F1, Mohammadshahi M1, Alavinejad P2, Rezazadeh A3, Zarei M4, Engali KA5. Abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder related to inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been considered as an anti-inflammatory factor. […]

Coenzyme Q10 and Heart Failure

April 12, 2016 Circulation: Heart Failure TAKE-HOME MESSAGE This review discusses the use of coenzyme Q10 for patients with heart failure. CoQ10 enhances the cardiac production of ATP through its antioxidant activity, and it may also improve endothelial dysfunction. Abstract Heart failure (HF) with either preserved or reduced ejection fraction is associated with increased morbidity […]

Recent Study Shows Nutraceuticals Improve Abnormal LDL-C

Posted on January 13, 2016 by Cleveland HeartLab Since statins are often discontinued due to tolerability problems, a study of dyslipidemic patients (n=100) post percutaneous coronary intervention by Marazzi and colleagues published in the Journal of the American College of Cardiology sought to determine the value of a combination of nutraceuticals (policosanol, folic acid, red […]

CoQ10 is reduced in plasma following treatment with statins

Pharmacol Res. 2015 Sep;99:329-36. doi: 10.1016/j.phrs.2015.07.008. Epub 2015 Jul 17. Statin therapy and plasma coenzyme Q10 concentrations-A systematic review and meta-analysis of placebo-controlled trials. Banach M Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Abstract Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is […]

The CoQ10-Statin Secret

Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S. The medical literature clearly shows that statin medications like Lipitor,Crestor, Zocor shut down the production of one of the most important nutrients in the body. And I am referring to Co-Enzyme Q10 (CoQ10). What many people are unaware of is the fact that when CoQ10 is depleted it causes the LDL […]

Ubiquinol-10 May Improve Symptoms of Parkinson’s Disease

Parkinsonism Relat Disord. 2015 May 29. pii: S1353-8020(15)00240-0. doi: 10.1016/j.parkreldis.2015.05.022. [Epub ahead of print] Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Yoritaka A1, Kawajiri S2, Yamamoto Y3, Nakahara T2, Ando M2, Hashimoto K3, Nagase M3, Saito Y4, Hattori N5. Abstract INTRODUCTION: Mitochondrial complex I deficiencies have been found in post-mortem […]

Reduction in Asymmetric dimethylarginine plasma levels by Coenzyme Q10 supplementation in patients with type 2 diabetes mellitus

Minerva Endocrinol. 2015 Jul 3. [Epub ahead of print] Hosseinzadeh-Attar M1, Kolahdouz Mohammadi R, Eshraghian M, Nakhjavani M, Khorrami E, Ebadi M, ‘Esteghamati A. Abstract AIM: According to many studies, supplementation with Coenzyme Q10 (CoQ10) yields beneficial results in terms of endothelial function in type 2 diabetes mellitus. Despite these promising results, data elucidating the […]

Long-term CoQ10 treatment of patients with chronic HF is safe, improves symptoms, and reduces major adverse cardiovascular events

JACC Heart Fail. 2014 Dec;2(6):641-9. doi: 10.1016/j.jchf.2014.06.008. Epub 2014 Oct 1. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP; Q-SYMBIO Study Investigators. Abstract OBJECTIVES: This […]

Co Q10 supplementation (50 mg twice daily) effectively reduced statin-related muscular symptoms

Med Sci Monit. 2014 Nov 6;20:2183-8. doi: 10.12659/MSM.890777. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Skarlovnik A, Janić M, Lunder M, Turk M, Šabovič M. Abstract BACKGROUND: Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether […]

Five ways to Eliminate Migraines. ~ Dr. Mark Hyman

Via Mark Hyman on Oct 4, 2014 If you’ve ever suffered a migraine, I don’t need to describe the feeling. These severe, nearly disabling headaches can last from hours to days and create nausea, vomiting, and severe throbbing pain on one or both sides of your head. In extreme cases, migraines can even carry stroke-like […]

Novel Intervention May Reverse Alzheimer’s Memory Loss

Novel Intervention May Reverse Alzheimer’s Memory Loss Pam HarrisonStory Source October 03, 2014 A novel, comprehensive lifestyle intervention has shown promise in reversing memory loss related to Alzheimer’s disease (AD), preliminary research suggests. According to investigators, this novel intervention is aimed at “tweaking” the network of imbalances in the brain that contribute to cognitive decline. “We’ve been […]

Alternative Medicine in Chronic Migraine 2014

Alternative Medicine in Chronic Migraine 2014: What Clinicians Need to Know Migraine patients are increasingly turning to complementary and alternative medicine (CAM) for therapy. Therefore, clinicians who treat headache patients should gain a basic understanding of the efficacy and safety of these therapies. By Soma Sahai-Srivastava, MD, Anne Csere, DO and Andrew Joyce, MD Practical […]

CoQ10 Reduces Serum Gamma Glutamyl Transpeptidase (GGT)

Reference: “Ubiquinol (Q10H2) reduces gamma glutamyltransferase (GGT) as a marker of oxidative stress in humans,” Onur S, Niklowitz P, et al, BMC Res Notes 2014 Jul 4; 7(1): 427. (Address: Institute of Human Nutrition and Food Science, Division of Molecular Prevention, Christian Albrechts University Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany. E-mail: sek@molprev.uni-kiel.de ). Summary: In […]

Selenium and Coenzyme Q10 Status in Idiopathic Male Infertility

Role of Selenium and Coenzyme Q10 Status in Idiopathic Male Infertility Summary: In a case-control study involving 59 subjects, out of which 44 were diagnosed with idiopathic male infertility and had abnormal sperm parameters and 15 had normal sperm parameters with proven fertility, serum levels of selenium (Se) were found to be positively associated with […]

Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy

A triple-blinded placebo and diet-controlled investigation Evans M, Rumberger JA, et al Vasc Health Risk Manag, 2014 Feb 27; 10: 89-100. PubMed Reference Journal Reference In a randomized, triple=blinded, placebo-controlled study involving patients with low to moderate risk of cardiovascular disease eligible for statin therapy, supplementation with pantethine – a derivative of vitamin B5 – […]