September 14, 2022 The Lancet TAKE-HOME MESSAGE This large meta-analysis investigated the effects of statins on muscle symptoms over time based on data from 154,664 participants in 23 double-blind trials. The relative increase of muscle pain or weakness was <10% (1 in 15 patients), mainly during the first year of statin use. It also confirmed […]
May 13, 2020 Naveed Saleh, MD, MS, for MDLinx Although statins are remarkably effective at lowering lipid levels, they have been mired in controversy, an imbroglio commonly referred to as the “statin wars.” Much of this controversy centers on the benefits of statins as primary prevention vs their adverse effects, most disconcertingly acute renal failure […]
Atherosclerosis — Kennedy C, et al. | March 12, 2020 Researchers performed this systematic review to determine if treatment with Coenzyme Q10 (CoQ10) can successfully improve symptoms and can ensure maintenance on statin therapy among patients with statin-associated myalgia. They analyzed relevant studies identified from MEDLINE, EMBASE and the Cochrane Library. For review, 8 studies […]
Am J Med Sci. 2014 Mar;347(3):211-6. doi: 10.1097/MAJ.0b013e31828318e2. Magulick JP1, Frei CR, Ali SK, Mortensen EM, Pugh MJ, Oramasionwu CU, Daniels KR, Mansi IA. Abstract BACKGROUND: Statins have been postulated to prevent infection through immunomodulatory effects. OBJECTIVES: To compare the incidence of infections in statin users to that in nonusers within the same health care […]
American Journal of Cardiovascular Drugs — Martinez AI, et al. | September 27, 2018 In this retrospective cohort study, researchers used data from the Truven Health MarketScan Research Database (2009–2015) to determine the risk of gastrointestinal (GI) hemorrhage in statin users aged 30–65 years at initial prescription claim. Study participants, negative control participants (ie, other […]
Retrospective Australian data suggest association with rare but severe condition by Nicole Lou, Contributing Writer, MedPage Today July 30, 2018 Autoimmune muscle inflammation was more likely to turn up among patients using statins than those not on these medications, according to an Australian population-based study. Statin use was seen in 30.8% of patients at the […]
Philip J. Gregory, PharmD March 10, 2017 Question Do low vitamin D levels increase the risk for myalgia in patients who are taking statins? About 1%-2% of patients who take hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins for hyperlipidemia develop muscle pain. This myalgia can feel like the aches and pains experienced with the flu. Muscles may […]
by Laura Donnelly 28 AUGUST 2016 • 5:00PM A Mediterranean diet could be better than statins at reducing the risk of an early death for millions of Britons, research suggests. Leading heart experts said patients should be prescribed the diet – rich in fruit, vegetables, fish, nuts, whole grains and olive oil – before being […]
Br J Clin Pharmacol. 2016 Apr 13. doi: 10.1111/bcp.12973. [Epub ahead of print] Ekhart C1, de Jong LA1, Gross-Martirosyan LD2, van Hunsel FP1. Author information 1Netherlands Pharmacovigilance Centre Lareb, ‘s-Hertogenbosch, The Netherlands. 2Dutch Medicines Evaluation Board Agency, Utrecht, The Netherlands. Abstract AIM: Statins are used in the treatment of hyperlipidaemia. They are among the most […]
By LUCY JOHNSTON PUBLISHED: 00:01, Sun, Sep 27, 2015 Scientists have found the heart disease drug badly affects our stem cells, the internal medical system which repairs damage to our bodies and protects us from muscle and joint pain as well as memory loss. Last night experts warned patients to “think very carefully” before taking […]
Pharmacol Res. 2015 Sep;99:329-36. doi: 10.1016/j.phrs.2015.07.008. Epub 2015 Jul 17. Statin therapy and plasma coenzyme Q10 concentrations-A systematic review and meta-analysis of placebo-controlled trials. Banach M Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Abstract Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is […]
Intake of polyunsaturated fat in relation to mortality among statin users and non-users in the Southern Community Cohort Study Nutrition, Metabolism & Cardiovascular Diseases, 08/06/2015 Kiage JN, et al. The results suggest potential benefits of PUFA consumption on mortality which are only apparent in the absence of statin therapy. It seems prudent to consider the […]
Is Your Doctor Harming You? This commentary was published in the peer-reviewed Journal of American Physicians and Surgeons Volume 20, Number 2, Pages 54-56, Summer 2015. Modern medicine has developed striking ways to treat coronary heart disease, which feature coronary stents implanted percutaneously and coronary artery bypass grafts performed surgically with the aid of a heart-lung […]
In a database study of nearly 26,000 beneficiaries of Tricare, the military health system, those taking statin drugs to control their cholesterol were 87 percent more likely to develop diabetes. The study, reported online April 28, 2015, in the Journal of General Internal Medicine, confirms past findings on the link between the widely prescribed drugs and […]
Troy Brown, RN May 22, 2015 Statin use for primary prevention of cardiovascular disease among healthy adults has been linked to an increased risk for diabetes, diabetes complications, and overweight/obesity in a new retrospective cohort study that tracked individuals in a database for an average of 6.5 years. “Whereas the increased risk of diabetes with statins is […]
ACA News – April 2015 Statin Myopathy: A Common Cause of Chronic Pain – James J. Lehman, DC A A A Statin myopathy is a common dilemma that causes persistent myalgia1 and chronic pain. Chiropractic physicians should be prepared to evaluate patients with these conditions. This article describes statin myopathy and its differential diagnosis.While primary care physicians and […]
Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Okuyama H1, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H. Author information Abstract In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery […]
Posted on June 14, 2004 by Sally Fallon and Mary G. Enig, PhD Hypercholesterolemia is the health issue of the 21st century. It is actually an invented disease, a “problem” that emerged when health professionals learned how to measure cholesterol levels in the blood. High cholesterol exhibits no outward signs–unlike other conditions of the blood, such as […]
January 16, 2015 The American Journal of Cardiology TAKE-HOME MESSAGE In this prospective study, researchers evaluated 4645 patients with vascular disease to determine the association between statin use and incident type 2 diabetes mellitus. Independent from metabolic syndrome characteristics, statin therapy, especially intensive statin therapy, was associated with an increased risk for type 2 diabetes. […]
Published: Nov 5, 2014 By Nancy Walsh, Senior Staff Writer, MedPage Today The regular use of statins, particularly among women, was associated with an increased risk of thyroid cancer, Taiwanese researchers reported. Compared with controls, patients who routinely used statins had an adjusted odds ratio for having thyroid cancer of 1.40 (95% CI 1.05-1.86, P<0.05), according […]