Osteoarthritis

Scientists discover link between gut microbiota and chronic inflammatory diseases like arthritis

MedicalXpress Breaking News-and-Events | January 25, 2022 An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis. The team led by Éric Boilard of Université Laval has discovered that a protein naturally present in the gut acts on the microbiota and causes the formation of molecules that […]

Topical Anti-Inflammatory Effective For Knee Osteoarthritis

November 07, 2021 BMJ : British Medical Journal TAKE-HOME MESSAGE This comprehensive systematic review and network meta-analysis assesses the efficacy and safety of multiple preparations and doses of NSAIDs, opioids, and acetaminophen for clinically relevant reductions in pain caused by knee and hip osteoarthritis. The review includes nearly 200 randomized controlled trials comprised of over 100,000 […]

Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis

October 26, 2021 A Randomized Clinical Trial Liam D. A. Paget, MD JAMA. 2021;326(16):1595-1605. doi:10.1001/jama.2021.16602 Key Points Question  Do intra-articular platelet-rich plasma injections improve ankle symptoms and function in patients with ankle osteoarthritis? Findings  In this randomized clinical trial that included 100 patients, treatment with 2 intra-articular platelet-rich plasma injections vs placebo injections with saline resulted in […]

Excess coffee consumption a culprit for poor health

Newswise: All Journal News May 13, 2020 Cappuccino, latte or short black, coffee is one of the most commonly consumed drinks in the world. But whether it’s good or bad for your health can be clarified by genetics, as a world-first study from the University of South Australia’s Australian Centre for Precision Health shows that excess coffee consumption can cause […]

Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update [Internet].

Editors Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Kantner S, Ferguson AJR. Source Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Apr. Report No.: 20-EHC009. AHRQ Comparative Effectiveness Reviews. Structured Abstract Objectives: We updated the evidence from our 2018 report assessing persistent […]

Are weather conditions associated with chronic musculoskeletal pain? Review of results and methodologies

Beukenhorst, Anna L.a, PAIN: April 2020 – Volume 161 – Issue 4 – p 668-683 doi: 10.1097/j.pain.0000000000001776 Abstract Many people believe that weather influences chronic musculoskeletal pain. Previous studies on this association are narratively reviewed, with particular focus on comparing methodologies and summarising study findings in light of study quality. We searched 5 databases (Medline, Embase, Web of […]

Foot and leg muscle weakness in people with midfoot osteoarthritis

Arthritis Care & Research — Arnold JB, Halstead J, Grainger AJ, et al. | April 20, 2020 Researchers performed this cross‐sectional study including people with symptomatic midfoot osteoarthritis (OA) and asymptomatic controls selected from general practices and community health clinics, to compare foot and leg muscle strength between these groups. Measurements were obtained for the […]

Diabetes in Osteoarthritis: Pain Is Worse

— Association was independent of obesity and radiographic severity by Nancy Walsh, Senior Staff Writer, MedPage Today March 3, 2020 Among patients with knee osteoarthritis (OA), pain was greater for those with coexisting diabetes mellitus (DM), and this association was independent of obesity and radiographic severity, European researchers found. In an analysis that adjusted for […]

Stress linked to inflammatory arthritis among at-risk individuals

Polinski KJ, Fontaine K. Arthritis Care Res. 2019;doi:10.1002/acr.24085. October 29, 2019 Perceived stress is significantly associated with developing inflammatory arthritis among those who are at risk, according to findings published in Arthritis Care & Research. “Stress is a part of everyday life, but how we perceive and cope with stressors can have potential impacts on our health,” Kristen J. Polinski, […]

The powerful placebo effect in osteoarthritis

Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):118-123. Epub 2019 Oct 15. Zhang W Abstract Osteoarthritis (OA) is the most common form of arthritis. Pain and its related function and stiffness are currently the major symptoms and primary outcomes for treatment. However, the treatment in the past has been primarily targeting on the peripheral changes in […]

Early Intervention in Osteoarthritis Has Potential to Help Control Pain and Disability, Reduce Work Loss

06.13.2019 by Julie Maurer Contributing Writer, MedPage Today When a patient is diagnosed with osteoarthritis (OA), his or her first instincts might be to reach for their medicine cabinet or wonder if surgery is in their future, but researchers say that early intervention with exercise and education is important. Canadian researchers have published a study about possible […]

Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization

Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. Lai HC Abstract Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway […]

The Role of Orthobiologics in the Management of Osteoarthritis and Focal Cartilage Defects

Benjamin J. Sherman, DO; Jorge Chahla, MD, PhD; Jason Glowney, MD; Rachel M. Frank, MD Orthopedics. 2019;42(2):66-73https://doi.org/10.3928/01477447-20190225-02 Posted March 21, 2019 Abstract Individuals with osteoarthritis have a diminished quality of life, and the condition is a major cause of disability. Newer biologic treatments have been developed that are believed to modify disease progression. These predominantly […]

Osteoarthritis Patients Who Start Opioids at Higher Doses Have Worse Outcomes

By Lorraine L. Janeczko October 24, 2018 NEW YORK (Reuters Health) – Patients with osteoarthritis who start opioid treatment at higher doses tend to have higher treatment-failure rates, according to an industry-sponsored study. The findings were presented in a poster September 13 at the International Association for the Study of Pain (IASP) World Congress on […]

Diclofenac tied to increased risk of heart problems

Reuters Health News | September 24, 2018 The commonly used painkiller diclofenac may be linked with an increased risk of heart problems, a large Danish study suggests. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that’s often used to treat arthritis and other painful joint conditions. In many countries, it’s available without a prescription. Researchers found […]

Osteoarthritis: Can an antioxidant offer protection?

Healthline/Medical News Today | September 17, 2018 In a recent series of experiments, scientists found that a specific antioxidant helps prevent the damage that osteoarthritis causes to cartilage. This may also have applications for bone and brain disorders. Osteoarthritis is the most common arthritis type, causing pain and stiffness in the joints as cartilage steadily […]

Worse Knee OA Linked with Depression

by Nancy Walsh, Senior Staff Writer, MedPage Today June 14, 2018 AMSTERDAM — Among patients with knee osteoarthritis (OA), greater structural disease severity and worse functional limitations were associated with an increased risk of developing depression, a researcher reported here. Compared with patients in the lowest quintile, patients in the highest quintile of disease structural severity as measured according […]

Women and OA: More Milk, Less Progression

Women who drank milk regularly had less progression of knee osteoarthritis, data from the Osteoarthritis Initiative showed. by Nancy Walsh, Senior Staff Writer, MedPage Today May 29, 2014 Women who drank milk regularly had less progression of knee osteoarthritis (OA), data from the Osteoarthritis Initiative showed. Compared with women who never drank milk, whose decrease […]

Complementary and alternative medicine for rheumatic diseases: A systematic review of randomized controlled trials.

Complement Ther Med. 2018 Apr;37:143-157. doi: 10.1016/j.ctim.2018.03.003. Epub 2018 Mar 5. Phang JK Abstract OBJECTIVES: To summarize all good quality randomized controlled trials (RCTs) using complementary and alternative medicine (CAM) interventions in patients with rheumatic diseases. METHODS: A systematic literature review guided by the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) was performed. […]

Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment?

Archives of Physical Medicine and Rehabilitation December 2017Volume 98, Issue 12, Pages 2485–2490 Daniel Pinto, PT, PhD Abstract Objective To investigate the relationship between sedentary behavior and quality-adjusted life years (QALYs) among participants in the Osteoarthritis Initiative. Design Longitudinal, observational design. Setting Osteoarthritis Initiative cohort. Participants Individuals (N=1794) from a prospective, multicenter longitudinal cohort were […]