Alexander M. Castellino, PhD December 11, 2014 National guidelines from associations such as the National Comprehensive Cancer Network (NCCN) and the American Urological Association recommend that men with a life expectancy of less than 10 years who have prostate cancer not be aggressively treated with radiation or surgery. Despite these recommendations, the Urologic Diseases in […]
Date: October 22, 2014 Source: University of Colorado Denver Summary: A new study offers compelling evidence that inflammation may be the link between vitamin D and prostate cancer. Specifically, the study shows that the gene GDF-15, known to be upregulated by vitamin D, is notably absent in samples of human prostate cancer driven by inflammation. […]
Bodo C Melnik, Swen M John, Pedro Carrera-Bastos, Loren Cordain Nutr Metab. 2012;9(74) Abstract Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key subsets of […]
Thomas L. Lenz, PharmD, MA, PAPHSDisclosures Am J Lifestyle Med. 2009;3(5):365-368. ABSTRACT AND INTRODUCTION Abstract It is estimated that approximately 1 billion people worldwide have blood concentrations of vitamin D that are considered suboptimal. Much research has been conducted over the past 30 years linking low vitamin D serum concentrations to both skeletal and nonskeletal […]
Date: August 25, 2014 Source: University of Oslo Summary: A possible molecular explanation for why overweight is harmful has been discovered by researchers. They suggest that overeating increases the immune response. This increased immune response causes the body to generate excessive inflammation, which may lead to a number of chronic diseases. This new knowledge may […]
Revamped Prostate Cancer Risk Calculator Now Online Fran Lowry August 08, 2014 The first version of the Prostate Cancer Risk Calculator, developed in 2006 to help men and their doctors assess their risk for prostate cancer, has been completely revamped. Version 2.0 uses current risk factors and gives a more nuanced result to help a man and his […]
Benefits Add Up for Regular Aspirin Use Published: Aug 5, 2014 | Updated: Aug 6, 2014 Discussant: Joseph Chao, MD. Average-risk adults in the general population who used aspirin regularly for at least 5 years had a lower risk of cancer, myocardial infarction (MI), stroke, and premature death, according to a comprehensive review of potential […]
MedPageToday.com Published: Jul 9, 2014 By Charles Bankhead, Staff Writer, MedPage Today Action Points Vasectomy was associated with an increased risk of prostate cancer overall and risk was elevated for high-grade and lethal disease. Point out however that the absolute increase in risk was relatively modest. Men who had a vasectomy had a significantly greater […]
PracticeUpdate.com RESEARCH · July 07, 2014 TAKE-HOME MESSAGE Analysis of 40,405 men from the Health Professionals Follow-Up Study found an increased risk for overall (HR, 1.10) and lethal (HR, 1.19) prostate cancer in men who underwent vasectomy, despite controlling for confounding factors. The overall risk for death from prostate cancer in the entire population was […]
Medscape Medical News > Oncology Fran Lowry June 30, 2014 The longer a person takes low-dose aspirin, the lower the risk for pancreatic cancer, according to a study published online June 26 in Cancer Epidemiology, Biomarkers & Prevention. This finding adds to increasing evidence of the preventive properties of aspirin in pancreatic and other cancers, said senior author Harvey A. […]
Cancer Prevention Research, 06/27/2014 > Clinical Article Albanes D, et al. – The authors examined whether pre–supplementation plasma α–tocopherol or γ–tocopherol was associated with overall or high–grade prostate cancer. The findings indicate that higher plasma α–tocopherol concentrations may interact with selenomethionine supplements to increase high–grade prostate cancer risk, suggesting a biological interaction between α–tocopherol and selenium itself […]
Published: Jun 10, 2014 | Updated: Jun 11, 2014 By Charles Bankhead, Staff Writer, MedPage Today Action Points Note that this review specifies suggested dietary guidance in which evidence of a dietary influence on cancer risk is substantial, but not necessarily conclusive. The review provides guidance based upon compelling evidence for cancer risk associated with […]
Published: Jun 2, 2014 By Ed Susman , Contributing Writer, MedPage Today CHICAGO — A structured physical exercise program appears to reduce cytokine production related to depression and inflammatory processes that may impact prostate cancer progression, researchers said here. Patients receiving usual care experienced a 0.08 log10 increase in pro-inflammatory interleukin-6 production, while patients treated […]
Published: May 21, 2014 By Charles Bankhead, Staff Writer, MedPage Today Action Points Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. ORLANDO — A diet rich in complex carbohydrates and fiber had a […]
Frontline Medical News, 2014 May 20, A Karon Full Story A biomarker panel distinguished individuals with pancreatic cancer from those who were healthy, had benign pancreatic cysts, or had chronic pancreatitis with about 90% accuracy, based on analyses of two cohorts. The panel, which tests for the known pancreatic cancer biomarker CA 19-9 plus three […]
American Urologic Association, 2014 May 18 Orlando, FL, May 18, 2014 – With an accuracy rating of 98 percent, specially-trained dogs were able to smell volatile organic compounds (VOCs) released into urine by prostate tumors, setting the stage for a potentially new means of early prostate cancer detection, according to a new study at the109th Annual Scientific […]
Published: May 2, 2014 | Updated: May 5, 2014 By Charles Bankhead, Staff Writer, MedPage Today Action Points In African-American men, vitamin D deficiency was associated with increased odds of prostate cancer diagnosis on biopsy. In both European-American and African-American men, severe vitamin D deficiency was positively associated with higher Gleason grade and tumor stage. […]
Results from the selenium and vitamin E cancer prevention trial Cancer Epidemiology, Biomarkers & Prevention, 04/18/2014 Clinical Article Kristal AR, et al. – The results of this study suggests that both low and high vitamin D concentrations were associated with increased risk of prostate cancer, and more strongly for high–grade disease. Methods Data for this case (n=1,731)–cohort […]
Conference Coverage Practice Update Tony Nimeh MD Friday May 16 1 – 5 p.m. Orange County Convention Center: Chapin Theater Moderator: Fritz H. Schroder, M.D. Pro: H. Ballentine Carter, MD Pro: Ian M. Thompson, Jr, MD Con: William J. Catalona, MD Con: Issac Powell Summary of the PRO arguments: 1- The guidelines follow the AUA […]
European Urology, 04/14/2014 Clinical Article Full Story PubMed Reference Journal Reference Kenfield SA, et al. – This study aims to determine whether the traditional Med–Diet pattern is associated with risk of incident advanced or lethal PCa and with PCa–specific and overall mortality among men with PCa. A higher Med–Diet score was not associated with risk of advanced […]