Drugs

A Warning From a Doctor Who Has Done Thousands of Steroid Injections for Arthritis

The extremely common treatment might be causing more harm than previously thought. JAMES HAMBLIN OCTOBER 17, 2019 After giving birth to a baby, a young woman told her nurses at Boston Medical Center that she was having pain in her hip. That happens sometimes after births, says Ali Guermazi, one of the doctors involved. As […]

Association Between Chiropractic Use and Opioid Receipt Among Patients with Spinal Pain: A Systematic Review and Meta-analysis

Pain Medicine, pnz219, https://doi.org/10.1093/pm/pnz219 Kelsey L Corcoran, DC Published:  27 September 2019 Abstract Objective To investigate the current evidence to determine if there is an association between chiropractic use and opioid receipt. Design Systematic review and meta-analysis. Methods The protocol for this review was registered on PROSPERO (CRD42018095128). The MEDLINE, PubMed, EMBASE, AMED, CINAHL, and Web of […]

Observational retrospective study of the association of initial healthcare provider for new-onset low back pain with early and long-term opioid use – Full Text

BMJ Open 2019;9:e028633. doi: 10.1136/bmjopen-2018-028633 First published September 20, 2019. Lewis E Kazis1, Omid Ameli1,2, James Rothendler1, Brigid Garrity1, Howard Cabral3, Christine McDonough4, Kathleen Carey1, Michael Stein1, Darshak Sanghavi2, David Elton5, Julie Fritz6, Robert Saper7 Abstract Objective This study examined the association of initial provider treatment with early and long-term opioid use in a national […]

Opioid Use Among Veterans of Recent Wars Receiving Veterans Affairs Chiropractic Care

Pain Med. 2018 Sep 1;19(suppl_1):S54-S60. doi: 10.1093/pm/pny114. Lisi AJ Abstract OBJECTIVE: To examine patient sociodemographic and clinical characteristics associated with opioid use among Veterans of Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) who receive chiropractic care, and to explore the relationship between timing of a chiropractic visit and receipt of an opioid prescription. METHODS: Cross-sectional analysis […]

Immune Responses Regulated by Cannabidiol

Cannabis and Cannabinoid Research James M. Nichols and Barbara L.F. Kaplan Published Online:4 Sep 2019 https://doi.org/10.1089/can.2018.0073 Abstract Introduction: Cannabidiol (CBD) as Epidiolex® (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance […]

Opioid usage patterns, patient characteristics, and the role of chiropractic services in a publicly funded inner city health care facility

Steven Passmore DC, PhD The Spine Journal Volume 19, Issue 9, Supplement, September 2019, Pages S78-S79 BACKGROUND CONTEXT Opioid prescription for spinal pain while common, is no longer recommended by recent clinical practice guidelines. Opioid prescription rates in the US and Canada are double those in most European countries. A recent study found chiropractic care […]

Paracetamol is ineffective for acute low back pain even for patients who comply with treatment

PAIN: August 23, 2019 – Volume Articles in Press – Issue – p doi: 10.1097/j.pain.0000000000001685 Abstract In 2014, the Paracetamol for Acute Low Back Pain (PACE) trial demonstrated that paracetamol had no effect compared with placebo in acute low back pain (LBP). However, noncompliance was a potential limitation of this trial. The aim of this study was to investigate the efficacy of paracetamol in acute […]

Do antidepressants work better than placebo?

Do antidepressants work better than placebo? Published Thursday 18 July 2019 By Tim Newman Scientists have been debating the efficacy of antidepressants for decades. The latest paper to throw its hat into the ring concludes that there is little evidence to show that they perform better than placebos. In 2017, around 17.3 million adults in the United […]

Effectiveness of Foot Orthoses Versus Corticosteroid Injection for Plantar Heel Pain: The SOOTHE Randomized Clinical Trial

Published: Journal of Orthopaedic & Sports Physical Therapy, 2019 Volume:49 Issue:7 Pages:491–500 DOI: 10.2519/jospt.2019.8807 Background Plantar heel pain is a common foot complaint that causes significant disability and poorer health-related quality of life. Foot orthoses and corticosteroid injection are effective treatments for plantar heel pain; however, it is unclear whether one is more effective than […]

What Are the Costs of Cervical Radiculopathy Prior to Surgical Treatment?

Injections $988 Physical Therapy: $510 Bracing: $193 Chiropractic services: $193 Narcotics: $101 Gabapentin: $93 NSAIDs: $47   Spine (Phila Pa 1976). 2019 Jul 1;44(13):937-942. doi: 10.1097/BRS.0000000000002983. Barton C Abstract STUDY DESIGN: Retrospective, observational study. OBJECTIVE: To examine the costs associated with nonoperative management (diagnosis and treatment) of cervical radiculopathy in the year prior to anterior […]

Gabapentinoids Tied to Suicidal Behavior and Unintentional Overdose

— New patterns emerge, especially for young people by Judy George, Senior Staff Writer, MedPage Today June 14, 2019 Gabapentinoid prescriptions were associated with an increased risk of suicidal behavior and unintentional overdose, a population cohort study in Sweden showed. The risks were strongest for people who were prescribed pregabalin (Lyrica) over gabapentin (Neurontin), especially […]

Non-surgical treatments for patients with radicular pain from lumbosacral disc herniation

The Spine Journal Available online 12 June 2019 Jung HwanLee MD, PhD. Abstract Background Context Lumbosacral disc herniation (LDH) is one of the most frequent musculoskeletal diseases causative of sick leave in the workplace and morbidity in daily activities. Non-surgical managements are considered as first line treatment before surgical treatment. Purpose This clinical practice guideline […]

Effectiveness of Foot Orthoses Versus Corticosteroid Injection for Plantar Heel Pain: The SOOTHE Randomized Clinical Trial

Study Design Randomized clinical trial. Background Plantar heel pain is a common foot complaint that causes significant disability and poorer health-related quality of life. Foot orthoses and corticosteroid injection are effective treatments for plantar heel pain, however it is unclear if one is more effective than the other. Therefore, the aim of this trial was […]

Heartburn Drugs Again Tied To Fatal Risks

MedicalXpress Breaking News-and-Events | June 07, 2019 People who use common heartburn drugs for months to years may face heightened risks of dying from heart disease, kidney failure or stomach cancer, a new study suggests. The study included more than 200,000 US veterans. It’s the latest to raise concerns over drugs called proton pump inhibitors […]

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies – Full Text Article

Cannabis and Cannabinoid Research Vol. 2, No. 1 Kerstin Iffland and Franjo Grotenhermen Published Online:1 Jun 2017 https://doi.org/10.1089/can.2016.0034 Abstract Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart from updating the literature, this article focuses on clinical studies and CBD […]

Chronic use of tramadol after acute pain episode: cohort study – Full Text Article

BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l1849 (Published 14 May 2019) Cite this as: BMJ 2019;365:l1849 Abstract Objective To determine the risk of prolonged opioid use in patients receiving tramadol compared with other short acting opioids. Design Observational study of administrative claims data. Setting United States commercial and Medicare Advantage insurance claims (OptumLabs Data Warehouse) January 1, 2009 through June […]

Common antibiotic may increase nerve damage and peripheral neuropathy risk

NEUROSCIENCE NEWS MAY 14, 2019 Summary: Fluoroquinolone antibiotics, such as Levofloxacin and Ciprofloxacin, appear to increase the risk of peripheral neuropathy by 47%. However, there is no significant increased risk of developing neuropathy associated with amoxicillin use. Source: University of Dundee Research from the University of Dundee has shown that a commonly used class of […]

Without heart disease, daily aspirin may be too risky

Reuters Health News | May 14, 2019 For people without heart disease, taking a daily aspirin to prevent heart attacks and strokes may increase the risk of severe intracranial bleeding to the point where the risk outweighs any potential benefit, a research review suggests. US doctors have long advised adults who haven’t had a heart […]

Metformin Use Linked to Worse Cognition, B-Vitamin Deficiency

By Reuters Staff April 15, 2019 NEW YORK (Reuters Health) – Metformin is associated with worse cognitive function in older adults, which could be explained by B-vitamin deficiency, new research suggests. “Fortified foods can provide a bioavailable source of B-vitamins and may be beneficial for maintaining better cognitive health in older people with or at […]

Effect of NSAIDs on Bone Healing Rates – A Meta-analysis

Wheatley, Benjamin M., MD; Nappo, Kyle E., MD; Christensen, Daniel L., MD; Holman, Ann M., MLS; Brooks, Daniel I., PhD; Potter, Benjamin K., MD JAAOS – Journal of the American Academy of Orthopaedic Surgeons: April 1, 2019 – Volume 27 – Issue 7 – p e330–e336 doi: 10.5435/JAAOS-D-17-00727 Introduction: NSAIDs inhibit osteogenesis and may result […]