Drugs

Inflammatory Myositis May Be More Common With Statin Use

Retrospective Australian data suggest association with rare but severe condition by Nicole Lou, Contributing Writer, MedPage Today July 30, 2018 Autoimmune muscle inflammation was more likely to turn up among patients using statins than those not on these medications, according to an Australian population-based study. Statin use was seen in 30.8% of patients at the […]

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: Analysis of individual patient data from randomised trials

The Lancet — Rothwell PM, et al. | July 20, 2018 In view of only modest benefits of a one-dose-fits-all approach to aspirin use for long-term prevention of cardiovascular events, researchers assessed aspirin in primary prevention of cardiovascular events by analyzing the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on […]

Women more likely than men to have acetaminophen-induced liver injury/failure

Wayne Kuznar, for MDLinx | July 20, 2018 Nearly three fourths of patients who present with acetaminophen-induced acute liver injury (ALI) or failure (ALF) are women, according to findings from a North American registry. Women with acetaminophen overdose leading to ALI/ALF were more likely than men to present with high-grade hepatic encephalopathy and have critical […]

Ozone therapy for low back pain. A systematic review.

Acta Reumatol Port. 2018 Jul 18. [Epub ahead of print] Costa T, Linhares D, Ribeiro da Silva M, Neves N. Abstract BACKGROUND: Low back pain associated with lumbar disc herniation is common in the general population, with evident repercussion in quality of life and a significant economic burden. Patients refractory to conservative treatment seek additional […]

FDA: New Warnings for Fluoroquinolones (Levaquin, Cipro, etc.)

– Class-wide label changes address mental health side effects, hypoglycemic coma risk by Molly Walker, Staff Writer, MedPage Today July 10, 2018 Manufacturers of fluoroquinolone antibiotics must update their labeling to warn about mental health issues and potential low blood sugar adverse reactions, the FDA said Tuesday. The labeling changes come after what the agency […]

Injured Veteran Credits Chiropractic With Saving Him From Opioid Addiction

Jane K. Martinez, Contributor Published 7:00 a.m. ET July 10, 2018 SOMERVILLE — At just 19-years-old, Joseph Faro of Bridgewater was robbed of his lifelong dream in the blink of an eye. He tries not to see it that way and, at 27 now, he is adjusting to life as a civilian, future accountant and […]

Spontaneous cervical artery dissection: a fluoroquinolone induced connective tissue disorder? – Full Text Article

James S. Demetrious Chiropractic & Manual Therapies 2018 26:22 https://doi.org/10.1186/s12998-018-0193-z Published: 9 July 2018 Background Spontaneous cervical artery dissections more often manifest in young people and have been associated with catastrophic consequences. Some indeterminate risk factors have been identified, making the diagnosis of developing dissections quite difficult. Fluoroquinolone antibiotics have been recognized for their degradative […]

Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Full Text Article

Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis Oliver Enke, Heather A. New, Charles H. New, Stephanie Mathieson, Andrew J. McLachlan, Jane Latimer, Christopher G. Maher and C.-W. Christine Lin CMAJ July 03, 2018 190 (26) E786-E793; DOI: https://doi.org/10.1503/cmaj.171333 Abstract BACKGROUND: The use of anticonvulsants (e.g., gabapentin, […]

Undercount Seen in Opioid Deaths

– Closer look increases toll by 70,000 during 1999-2015 by Judy George, Contributing Writer, MedPage Today June 27, 2018 The number of fatal opioid overdoses may have been higher than previously reported, with some states greatly underestimating the effect of opioid-related deaths, an analysis of National Center for Health Statistics data suggests. Potentially 70,000 opioid-related overdose deaths from 1999 to […]

Association of rapidly destructive osteoarthritis of the hip with intra-articular steroid injections – Full Text Article

Arthroplast Today. 2018 Jun; 4(2): 205–209. Published online 2018 May 7. doi: 10.1016/j.artd.2017.12.002 PMCID: PMC5994787 PMID: 29896554 Shane R. Hess, DO Abstract Background To assess the relationship between rapidly destructive osteoarthritis (RDOA) of the hip and intra-articular steroid injections. Methods Coding records from 2000 to 2013 were used to identify all subjects who had a […]

More evidence of NSAID risk in early pregnancy

More evidence of NSAID risk in early pregnancy Reuters Health News | June 21, 2018 Using non-steroidal anti-inflammatory drugs (NSAIDs) around the time of conception significantly increases the risk of miscarriage in the first 8 weeks of pregnancy, a study suggests. Researchers compared newly pregnant women who used NSAIDs around the time of conception or […]

The Burden of Opioid-Related Mortality in the United States – Full Text

June 2018 Tara Gomes, PhD Key Points Question  What has been the burden of opioid-related deaths in the United States over a recent 15-year period? Findings  In this serial cross-sectional study, we found that the percentage of all deaths attributable to opioids increased 292% (from 0.4% to 1.5%) between 2001 and 2016, resulting in approximately 1.68 million person-years of […]

Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials

Di Yalong Arthritis Research & Therapy 2018 20:128 https://doi.org/10.1186/s13075-018-1621-0© The Author(s). 2018 Received: 16 September 2017Accepted: 13 May 2018 Published: 19 June 2018 Abstract Background In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. Methods The Cochrane Central Register of Controlled Trials, PubMed, […]

Opioid Prescribing and Polypharmacy in Children with Chronic Musculoskeletal Pain

Sabrina Gmuca, MD, MSCE Pain Medicine, pny116, https://doi.org/10.1093/pm/pny116 Published: 13 June 2018 Abstract Objective Thirty percent of adults with fibromyalgia receive an opioid, but the prevalence of opioid prescribing in pediatric chronic musculoskeletal pain is unknown. The aims of this study were to determine the prevalence of and factors associated with opioid exposure and polypharmacy […]

Many US adults take medicines that can cause depression

Reuters Health News | June 13, 2018 More than one-third of American adults take medications that have the potential to cause depression, a US study suggests. These include drugs for birth control, heartburn, allergies, pain, and hypertension. As of 2015, about 38% of adults took one medicine with depression as a known side effect, up […]

A case report of multiple cervical artery dissection after peripheral type facial palsy and use of steroids

BMC Neurol. 2018; 18: 74. Published online 2018 May 28. doi: 10.1186/s12883-018-1080-x PMCID: PMC5971422 PMID: 29807531 Sung eun Chung, Abstract Background Cervical artery dissection is one of the most important causes of ischemic stroke in young age patients. However, multiple cervical artery dissection simultaneously involving the anterior and posterior circulation is uncommon. Here, we would […]

Use of Acid-Suppressive Medications and Antibiotics During Infancy Associated With Allergic Diseases in Early Childhood

April 19, 2018 JAMA Pediatrics TAKE-HOME MESSAGE A large cohort of 792,130 children was retrospectively assessed to evaluate the association between exposure to acid-suppressive medications and antibiotics in the first 6 months of life and the risk of allergic diseases in early childhood. Histamine-2 receptor antagonists (H2RAs) were prescribed for 7.6% of children, while 1.7% […]

Many People Taking Antidepressants Discover They Cannot Quit

By BENEDICT CAREY and ROBERT GEBELOFF APRIL 7, 2018 Victoria Toline would hunch over the kitchen table, steady her hands and draw a bead of liquid from a vial with a small dropper. It was a delicate operation that had become a daily routine — extracting ever tinier doses of the antidepressant she had taken […]

Thousands of patients given ‘useless’ back-pain injection every year

Tens of thousands of patients are given a ‘useless’ back-pain injection that costs the NHS nearly £40 million ($567 million) each year Patients demanding a ‘quick fix’ are given the treatment at £540 ($765) per procedure Doctors are advised not to give the therapy but instead recommend exercise Previous research suggests painkillers and rest are wrongly […]

Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancer

March 28, 2018 Journal of the American Academy of Dermatology TAKE-HOME MESSAGE This retrospective study sought to determine if hydrochlorothiazide use was linked to the development of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), the nonmelanoma skin cancers (NMSC). Researchers examined data from the Danish Cancer Registry from 2004 to 2012 and the […]