SSRIs

Antidepressants at Normal Doses Linked to First-Time Seizures

Daniel M. Keller, PhD April 06, 2015 VIENNA — Antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs), have been linked to an increased risk for first- time seizures in patients being treated for depression, new research shows. Results of a study conducted by investigators at the University of Basel, in Switzerland, showed […]

Antidepressants Blunt Sexual Function, Feelings of Love

Medscape Medical News from the: 27th European College of Neuropsychopharmacology (ECNP) Congress Medscape Medical News > Psychiatry Antidepressants Blunt Sexual Function, Feelings of Love Deborah Brauser October 20, 2014 BERLIN ― Long-term antidepressant use may be associated with significant “emotional blunting” in both male and female patients ― but in different ways, new research suggests. […]

Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Gwen M.C. Masclee Gastroenterology Volume 147, Issue 4, Pages 784–792.e9, October 2014 Background & Aims Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB […]

SSRIs, Hypnotics Increase Fracture Risk

Medscape Medical News from: The American Society for Bone and Mineral Research (ASBMR) 2014 Story Source September 22, 2014 HOUSTON, Texas — Use of hypnotic medications for insomnia and use of selective serotonin reuptake inhibitors (SSRIs) are each associated with an increased risk for osteoporotic and hip fractures in older women and men, independent of other risk factors on […]

Stopping SSRIs Before Pregnancy Does Not Reduce Miscarriages

Medscape Medical News Neil Osterweil September 09, 2014 Women who take selective serotonin reuptake inhibitors (SSRIs) for depression during early pregnancy and those who stop taking the drugs up to a year before becoming pregnant have similar risks for miscarriage, investigators in a large, population-based study have found. The results suggest there is no causal […]

Maternal Antidepressant Use Linked to Infant Brain Malformations

Medscape Medical News > Psychiatry Deborah Brauser May 23, 2014 Maternal antidepressant use may be associated with structural brain changes in infants, according to new imaging research. A retrospective cohort study of 33 children showed that the offspring of mothers who used selective serotonin reuptake inhibitors (SSRIs) during pregnancy were significantly more likely to develop […]

Upper GI Bleeding With SSRIs

Research · April 29, 2014 TAKE-HOME MESSAGE This analysis of 15 case-control studies (n = 393,268) and 4 cohort studies found an increased risk of upper GI bleeding with selective serotonin reuptake inhibitors (SSRIs; OR, 1.66; 95% CI, 1.44–1.92). The addition of NSAIDs further increased this risk (OR, 4.25; 95% CI, 2.82–6.42). SSRIs modestly increase […]

Prenatal SSRI Use May Increase Autism Risk

Research · April 14, 2014 TAKE-HOME MESSAGE In 966 mother–child pairs, including children with autism spectrum disorders (ASDs), developmental delays (DDs), and typical development (TD), boys with ASD were three times more likely than children with TD to have been prenatally exposed to selective serotonin reuptake inhibitors (SSRIs), and children with DDs were also more […]

Prenatal SSRI Use May Be Linked to Autism Spectrum Disorder

Laurie Barclay, MD April 14, 2014 Prenatal use of selective serotonin reuptake inhibitors (SSRIs) appears to be a risk factor for autism spectrum disorders (ASDs) and other developmental delays (DDs) in young children, but underlying maternal depression may be a confounder, according to findings of a population-based case-control study published online April 14 in Pediatrics. “Serotonin is critical […]

Anti-Anxiety Drugs Tied to Higher Mortality

By NICHOLAS BAKALAR MARCH 27, 2014, 3:57 PM A large study has linked several common anti-anxiety drugs and sleeping pills to an increased risk of death, although it’s not certain the drugs were the cause. For more than seven years, researchers followed 34,727 people who filled prescriptions for anti-anxiety medications like Valium and Xanax, or […]

Effect of Commonly Used Drugs and Supplements on Cognition in Older Adults

Alzheimers Dement 2013 Nov 01;9(6)724-732, KR Obermann, JC Morris, CM Roe Research · December 19, 2013 Practice Update Website Story:  http://www.practiceupdate.com/journalscan/7193 Journal Abstract:  http://www.alzheimersanddementia.com/article/S1552-5260(12)02574-5/abstract TAKE-HOME MESSAGE Results of this exploratory analysis of 100 drugs showed that common medications used by older adults, 10% in this study, are associated with increases or decreases in cognitive performance. […]

Pregnancy: Mixed Results SSRI-Autism Link

…”there was a significantly increased risk among women who received SSRIs before pregnancy but not during pregnancy.”

SSRIs Linked to Bleeding Risk, Death in Surgical Patients

Caroline Cassels April 30, 2013 Perioperative use of selective serotonin reuptake inhibitors (SSRIs) has been linked to an increased risk of bleeding, transfusion, hospital readmission, and death, new research shows. A large retrospective study that included 375 US hospitals and more than half a million adult patients showed that receiving SSRIs in the perioperative period […]